Title :

Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway.

Author(s) :

Mauro, Silva [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Decoster, Laurine [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Trova, Sara [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Mimouni, N. E. H. [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Delli, Virginia [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Chachlaki, Konstantina [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Yu, Q. [Auteur]
University of Saarland / Universität des Saarlandes [Homburg, Germany]
Boehm, U. [Auteur]
University of Saarland / Universität des Saarlandes [Homburg, Germany]
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Giacobini, Paolo [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Proceedings of the National Academy of Sciences of the United States of America

Abbreviated title :

Proc. Natl. Acad. Sci. U.S.A.

Volume number :

119

Pages :

e2203503119

Publication date :

2022-07-22

ISSN :

1091-6490

Keyword(s) :

PCOS
AMH
sexual behavior
nitric oxide
hypothalamus

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and sexual satisfaction. While the hypothalamus is known to regulate sexual behavior, the specific neuronal pathways ...
Show more >Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and sexual satisfaction. While the hypothalamus is known to regulate sexual behavior, the specific neuronal pathways affected in patients with PCOS are not known. To dissect the underlying neural circuitry, we capitalized on a robust preclinical animal model that reliably recapitulates all cardinal PCOS features. We discovered that female mice prenatally treated with anti-Müllerian hormone (PAMH) display impaired sexual behavior and sexual partner preference over the reproductive age. Blunted female sexual behavior was associated with increased sexual rejection and independent of sex steroid hormone status. Structurally, sexual dysfunction was associated with a substantial loss of neuronal nitric oxide synthase (nNOS)-expressing neurons in the ventromedial nucleus of the hypothalamus (VMH) and other areas of hypothalamic nuclei involved in social behaviors. Using in vivo chemogenetic manipulation, we show that nNOSVMH neurons are required for the display of normal sexual behavior in female mice and that pharmacological replenishment of nitric oxide restores normal sexual performance in PAMH mice. Our data provide a framework to investigate facets of hypothalamic nNOS neuron biology with implications for sexual disturbances in PCOS.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-16T00:58:07Z
2025-02-26T09:43:27Z