Titre :

Functional networks underlying freezing of gait: a resting-state electroencephalographic study.

Auteur(s) :

Bayot, Madli [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer [JPArc - U1172 Inserm]
Gerard, Morgane [Auteur]
Derambure, Philippe [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Betrouni, Nacim [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Delval, Arnaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

Clinical Neurophysiology

Nom court de la revue :

Neurophysiol Clin

Date de publication :

2022-04-08

ISSN :

1769-7131

Mot(s)-clé(s) :

Electroencephalo-graphy
Freezing of gait
Functional connectivity
Resting state
Spectral analysis

Mot(s)-clé(s) en anglais :

Spectral analysis
Resting state
Functional connectivity
Freezing of gait
Electroencephalo-graphy

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction: The pathophysiology of freezing of gait in people with Parkinson's disease (PD) remains unclear, despite its association with motor, cognitive, limbic and sensory-perceptual impairments. Resting-state ...
Lire la suite >Introduction: The pathophysiology of freezing of gait in people with Parkinson's disease (PD) remains unclear, despite its association with motor, cognitive, limbic and sensory-perceptual impairments. Resting-state electroencephalography (EEG) may provide functional information for a better understanding of freezing of gait by studying spectral power and connectivity between brain regions in different frequency bands. Methods: High-resolution EEG was recorded in 36 patients with PD (18 freezers, 18 non-freezers), and 18 healthy controls during a 5-min resting-state protocol with eyes open, followed by a basic spectral analysis in the sensor space and a more advanced analysis of functional connectivity at the source level. Results: Freezers showed a diffusely higher theta-band relative spectral power than controls. This increased power was correlated with a deficit in executive control. Concerning resting-state functional connectivity, connectivity strength within a left fronto-parietal network appeared to be higher in freezers than in controls in the theta band, and to be correlated with freezing severity and a history of falls. Conclusion: We have shown that spectral power and connectivity analyses of resting-state EEG provide useful and complementary information to better understand freezing of gait in PD. The higher connectivity strength seen within the left ventral attention network in freezers is in keeping with an excessive guidance of behavior by external cues, due to executive dysfunction, and spectral analysis also found changes in freezers that was closely correlated with executive control deficits. This exaggerated influence of the external environment might result in behavioral consequences that contribute to freezing of gait episodes. These findings should be further investigated with a longitudinal study.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2024-01-16T01:20:15Z
2025-02-19T10:06:42Z