Association of Amyotrophic Lateral Sclerosis ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Association of Amyotrophic Lateral Sclerosis and Alzheimer's Disease: New Entity or Coincidence? A Case Series.
Author(s) :
Vrillon, Agathe [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Deramecourt, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Magnin, Éloi [Auteur]
Service de Neurologie [CHRU Besançon]
Wallon, David [Auteur]
Génétique du cancer et des maladies neuropsychiatriques [GMFC]
Lozeron, Pierre [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Bouaziz-Amar, Élodie [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Paquet, Claire [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Deramecourt, Vincent [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Magnin, Éloi [Auteur]
Service de Neurologie [CHRU Besançon]
Wallon, David [Auteur]
Génétique du cancer et des maladies neuropsychiatriques [GMFC]
Lozeron, Pierre [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Bouaziz-Amar, Élodie [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Paquet, Claire [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Journal title :
Journal of Alzheimer's Disease
Volume number :
84
Pages :
1439-1446
Publication date :
2021-10-26
ISSN :
1875-8908
Keyword(s) :
Alzheimer's disease
amyotrophic lateral sclerosis
cerebrospinal fluid biomarkers
neurodegenerative disorders
neuropathology
amyotrophic lateral sclerosis
cerebrospinal fluid biomarkers
neurodegenerative disorders
neuropathology
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 ...
Show more >Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.Show less >
Show more >Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-16T01:43:48Z
2024-06-10T14:20:43Z
2024-06-10T14:20:43Z