Tanycytic networks mediate energy balance ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.
Auteur(s) :
Lhomme, Tori [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Clasadonte, Jerome [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Imbernon, Monica [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Fernandois, Daniela [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Sauve, Florent [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Caron, Emilie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lima, N. [Auteur]
Heras, V. [Auteur]
Martinez Corral, Ines [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Müller-Fielitz, H. [Auteur]
Rasika, Sowmyalakshmi [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Schwaninger, M. [Auteur]
Nogueiras, R. [Auteur]
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Clasadonte, Jerome [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Imbernon, Monica [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Fernandois, Daniela [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Sauve, Florent [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Caron, Emilie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lima, N. [Auteur]
Heras, V. [Auteur]
Martinez Corral, Ines [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Müller-Fielitz, H. [Auteur]
Rasika, Sowmyalakshmi [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Schwaninger, M. [Auteur]
Nogueiras, R. [Auteur]
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Titre de la revue :
The Journal of clinical investigation
Numéro :
131
Pagination :
e140521
Éditeur :
American Society for Clinical Investigation
Date de publication :
2021-07-31
ISSN :
1558-8238
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes of the arcuate nucleus ...
Lire la suite >Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes of the arcuate nucleus of the hypothalamus, specialized glia that line the wall of the third ventricle, convert brain glucose supplies into lactate that they transmit through monocarboxylate transporters to arcuate proopiomelanocortin neurons, which integrate this signal to drive their activity and to adapt the metabolic response to meet physiological demands. Furthermore, this transmission required the formation of extensive connexin-43 gap junction–mediated metabolic networks by arcuate tanycytes. Selective suppression of either tanycytic monocarboxylate transporters or gap junctions resulted in altered feeding behavior and energy metabolism. Tanycytic intercellular communication and lactate production are thus integral to the mechanism by which hypothalamic neurons that regulate energy and glucose homeostasis efficiently perceive alterations in systemic glucose levels as a function of the physiological state of the organism.Lire moins >
Lire la suite >Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes of the arcuate nucleus of the hypothalamus, specialized glia that line the wall of the third ventricle, convert brain glucose supplies into lactate that they transmit through monocarboxylate transporters to arcuate proopiomelanocortin neurons, which integrate this signal to drive their activity and to adapt the metabolic response to meet physiological demands. Furthermore, this transmission required the formation of extensive connexin-43 gap junction–mediated metabolic networks by arcuate tanycytes. Selective suppression of either tanycytic monocarboxylate transporters or gap junctions resulted in altered feeding behavior and energy metabolism. Tanycytic intercellular communication and lactate production are thus integral to the mechanism by which hypothalamic neurons that regulate energy and glucose homeostasis efficiently perceive alterations in systemic glucose levels as a function of the physiological state of the organism.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2024-01-16T01:57:40Z
2024-10-30T10:01:18Z
2024-10-30T10:01:18Z