Titre :

Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?

Auteur(s) :

Degraeve, Béatrice [Auteur]
Experience ; Technology & Human Interactions ; Care & Society : [ETHICS EA 7446]
Sequeira, Henrique [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Mecheri, Halima [Auteur]
Université catholique de Lille - Faculté des lettres et sciences humaines [UCL FLSH]
Lenne, Bruno [Auteur]
Université catholique de Lille [UCL]
Hôpital Saint Vincent de Paul de Lille

Titre de la revue :

Multiple Sclerosis Journal

Nom court de la revue :

Mult Scler

Numéro :

29

Pagination :

p.160-168

Éditeur :

SAGE Publications

Date de publication :

2023-02

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages ...
Lire la suite >The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS. For this purpose, we will first review structural and functional evidence of callosal pathology in MS. Second, we will account for the potential role of CC abnormalities in MS-related dysfunctions. Finally, we will report data concurring with a “multiple disconnection hypothesis” that has been proposed to explain those dysfunctions, and we will examine evidence pointing toward MS as a “callosal disconnection syndrome.” We will end by discussing the contribution of this interpretation to the understanding of MS and MS-related deficits.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Dynamique Émotionnelle et Pathologies (DEEP)

Date de dépôt :

2024-01-17T14:27:14Z
2024-02-12T10:52:30Z
2024-02-20T10:41:34Z