Signatures of alcohol use in the structure ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study
Auteur(s) :
Betka, Sophie [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Harris, Lisa [Auteur]
Rae, Charlotte [Auteur]
Palfi, Bence [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Harris, Lisa [Auteur]
Rae, Charlotte [Auteur]
Palfi, Bence [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]
Titre de la revue :
Psychopharmacology
Nom court de la revue :
Psychopharmacology
Numéro :
236
Pagination :
p.2579-2591
Éditeur :
Springer Science and Business Media LLC
Date de publication :
2019-09-01
Mot(s)-clé(s) en anglais :
Addiction
Insula
Interoception
Magnetic resonance spectroscopy
Alcohol use
Voxel/surface-based morphometry
Craving
Insula
Interoception
Magnetic resonance spectroscopy
Alcohol use
Voxel/surface-based morphometry
Craving
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
Rationale
Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and ...
Lire la suite >Rationale Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and drug use disorders. Alcohol-associated insular dysfunction may arise through aberrant glutamatergic neurotransmission associated with selective neuronal death and atrophy. Objective In a sample of alcohol users, we combined magnetic resonance spectroscopy (MRS) with voxel and surface-based morphometry (VBM, SBM) to test the hypothesis that the neurochemical and structural properties of the insula relate to alcohol use. Methods Twenty-three healthy individuals were characterized by measures of alcohol use and subjective craving. Right mid-insula glutamate/glutamine (Glx) and total N-acetylaspartate/N-acetyl-aspartylglutamate (TNAA) concentrations were measured using MRS. Right insular structure was quantified using VBM and SBM parameters. We tested for predictive associations between these neuroimaging and behavioral/psychometric measures using Bayesian statistics. Results Reduced insular Glx concentration was associated with increased alcohol compulsions and, to a lesser extent, with greater alcohol use severity. Anecdotal evidence for a negative relationship between alcohol use severity and levels of insular gyrification was also observed. Conclusions This study is, to date, the first characterization of the neurochemical and morphological integrity of insular cortex in alcohol users. Our data seem to reveal a negative relationship between alcohol use and the neurochemical and structural integrity of the insula, a critical substrate for motivational behavior. These neurobiological characteristics might contribute to loss of control toward compulsive drinking with prolonged and excessive alcohol use.Lire moins >
Lire la suite >Rationale Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and drug use disorders. Alcohol-associated insular dysfunction may arise through aberrant glutamatergic neurotransmission associated with selective neuronal death and atrophy. Objective In a sample of alcohol users, we combined magnetic resonance spectroscopy (MRS) with voxel and surface-based morphometry (VBM, SBM) to test the hypothesis that the neurochemical and structural properties of the insula relate to alcohol use. Methods Twenty-three healthy individuals were characterized by measures of alcohol use and subjective craving. Right mid-insula glutamate/glutamine (Glx) and total N-acetylaspartate/N-acetyl-aspartylglutamate (TNAA) concentrations were measured using MRS. Right insular structure was quantified using VBM and SBM parameters. We tested for predictive associations between these neuroimaging and behavioral/psychometric measures using Bayesian statistics. Results Reduced insular Glx concentration was associated with increased alcohol compulsions and, to a lesser extent, with greater alcohol use severity. Anecdotal evidence for a negative relationship between alcohol use severity and levels of insular gyrification was also observed. Conclusions This study is, to date, the first characterization of the neurochemical and morphological integrity of insular cortex in alcohol users. Our data seem to reveal a negative relationship between alcohol use and the neurochemical and structural integrity of the insula, a critical substrate for motivational behavior. These neurobiological characteristics might contribute to loss of control toward compulsive drinking with prolonged and excessive alcohol use.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Équipe(s) de recherche :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Date de dépôt :
2024-01-17T14:45:27Z
2024-02-12T15:27:33Z
2024-02-12T15:27:33Z