Signatures of alcohol use in the structure ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study
Author(s) :
Betka, Sophie [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Harris, Lisa [Auteur]
Rae, Charlotte [Auteur]
Palfi, Bence [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Harris, Lisa [Auteur]
Rae, Charlotte [Auteur]
Palfi, Bence [Auteur]
Pfeifer, Gaby [Auteur]
Sequeira, Henrique [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Duka, Theodora [Auteur]
Critchley, Hugo [Auteur]
Journal title :
Psychopharmacology
Abbreviated title :
Psychopharmacology
Volume number :
236
Pages :
p.2579-2591
Publisher :
Springer Science and Business Media LLC
Publication date :
2019-09-01
English keyword(s) :
Addiction
Insula
Interoception
Magnetic resonance spectroscopy
Alcohol use
Voxel/surface-based morphometry
Craving
Insula
Interoception
Magnetic resonance spectroscopy
Alcohol use
Voxel/surface-based morphometry
Craving
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Rationale
Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and ...
Show more >Rationale Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and drug use disorders. Alcohol-associated insular dysfunction may arise through aberrant glutamatergic neurotransmission associated with selective neuronal death and atrophy. Objective In a sample of alcohol users, we combined magnetic resonance spectroscopy (MRS) with voxel and surface-based morphometry (VBM, SBM) to test the hypothesis that the neurochemical and structural properties of the insula relate to alcohol use. Methods Twenty-three healthy individuals were characterized by measures of alcohol use and subjective craving. Right mid-insula glutamate/glutamine (Glx) and total N-acetylaspartate/N-acetyl-aspartylglutamate (TNAA) concentrations were measured using MRS. Right insular structure was quantified using VBM and SBM parameters. We tested for predictive associations between these neuroimaging and behavioral/psychometric measures using Bayesian statistics. Results Reduced insular Glx concentration was associated with increased alcohol compulsions and, to a lesser extent, with greater alcohol use severity. Anecdotal evidence for a negative relationship between alcohol use severity and levels of insular gyrification was also observed. Conclusions This study is, to date, the first characterization of the neurochemical and morphological integrity of insular cortex in alcohol users. Our data seem to reveal a negative relationship between alcohol use and the neurochemical and structural integrity of the insula, a critical substrate for motivational behavior. These neurobiological characteristics might contribute to loss of control toward compulsive drinking with prolonged and excessive alcohol use.Show less >
Show more >Rationale Insular cortex supports the representation of motivational feelings through the integration of interoceptive information concerning bodily physiology. Compromised insular integrity is implicated in alcohol and drug use disorders. Alcohol-associated insular dysfunction may arise through aberrant glutamatergic neurotransmission associated with selective neuronal death and atrophy. Objective In a sample of alcohol users, we combined magnetic resonance spectroscopy (MRS) with voxel and surface-based morphometry (VBM, SBM) to test the hypothesis that the neurochemical and structural properties of the insula relate to alcohol use. Methods Twenty-three healthy individuals were characterized by measures of alcohol use and subjective craving. Right mid-insula glutamate/glutamine (Glx) and total N-acetylaspartate/N-acetyl-aspartylglutamate (TNAA) concentrations were measured using MRS. Right insular structure was quantified using VBM and SBM parameters. We tested for predictive associations between these neuroimaging and behavioral/psychometric measures using Bayesian statistics. Results Reduced insular Glx concentration was associated with increased alcohol compulsions and, to a lesser extent, with greater alcohol use severity. Anecdotal evidence for a negative relationship between alcohol use severity and levels of insular gyrification was also observed. Conclusions This study is, to date, the first characterization of the neurochemical and morphological integrity of insular cortex in alcohol users. Our data seem to reveal a negative relationship between alcohol use and the neurochemical and structural integrity of the insula, a critical substrate for motivational behavior. These neurobiological characteristics might contribute to loss of control toward compulsive drinking with prolonged and excessive alcohol use.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Submission date :
2024-01-17T14:45:27Z
2024-02-12T15:27:33Z
2024-02-12T15:27:33Z