The Fight against Poliovirus Is Not Over

Mbani, Chaldam Jespère; Nekoua, Magloire Pandoua; Moukassa, Donatien; Hober, Didier

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.3390/microorganisms11051323

PMID :

37317297

URL permanente :

http://hdl.handle.net/20.500.12210/102817

Titre :

The Fight against Poliovirus Is Not Over

Auteur(s) :

Mbani, Chaldam Jespère [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de virologie - ULR 3610
Moukassa, Donatien [Auteur]

Hober, Didier [Auteur]

Laboratoire de virologie - ULR 3610

Titre de la revue :

Microorganisms

Nom court de la revue :

Microorganisms

Numéro :

Pagination :

1323

Date de publication :

2023-06-13

ISSN :

2076-2607

Mot(s)-clé(s) en anglais :

eradication
vaccine-derived poliovirus
reversion
vaccine
poliovirus

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie

Résumé en anglais : [en]

Poliovirus (PV), the virus that causes both acute poliomyelitis and post-polio syndrome, is classified within the Enterovirus C species, and there are three wild PV serotypes: WPV1, WPV2 and WPV3. The launch of the Global ...
Lire la suite >Poliovirus (PV), the virus that causes both acute poliomyelitis and post-polio syndrome, is classified within the Enterovirus C species, and there are three wild PV serotypes: WPV1, WPV2 and WPV3. The launch of the Global Polio Eradication Initiative (GPEI) in 1988 eradicated two of the three serotypes of WPV (WPV2 and WPV3). However, the endemic transmission of WPV1 persists in Afghanistan and Pakistan in 2022. There are cases of paralytic polio due to the loss of viral attenuation in the oral poliovirus vaccine (OPV), known as vaccine-derived poliovirus (VDPV). Between January 2021 and May 2023, a total of 2141 circulating VDPV (cVDPV) cases were reported in 36 countries worldwide. Because of this risk, inactivated poliovirus (IPV) is being used more widely, and attenuated PV2 has been removed from OPV formulations to obtain bivalent OPV (containing only types 1 and 3). In order to avoid the reversion of attenuated OPV strains, the new OPV, which is more stable due to genome-wide modifications, as well as sabin IPV and virus-like particle (VLP) vaccines, is being developed and offers promising solutions for eradicating WP1 and VDPV.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

Laboratoire de virologie - ULR 3610

Date de dépôt :

2024-01-17T22:02:02Z
2024-02-13T10:27:35Z

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microorganisms-11-01323-v2.pdf
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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/102817*	2024-02-13T10:24:42Z
1	20.500.12210/102817.1	2024-01-17T22:02:02Z

The Fight against Poliovirus Is Not Over

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