Title :

Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age.

Author(s) :

Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Hirabidian, Mickael [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Rabat, Anthony [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Ouafi, Mahdi [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de virologie - ULR 3610
Sane, Famara [Auteur]
Laboratoire de virologie - ULR 3610
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
L. I. C. O. R. N. E., The Lille Covid Research Network [Auteur]

Journal title :

Journal of Clinical Medicine

Abbreviated title :

J Clin Med

Volume number :

11

Pages :

961

Publication date :

2022-02-26

ISSN :

2077-0383

English keyword(s) :

SARS-CoV-2
age
IFN alpha
neutralizing antibodies
severe COVID-19

HAL domain(s) :

Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression ...
Show more >Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Submission date :

2024-01-17T22:09:35Z
2024-02-14T08:53:31Z