Title :

Neurophysiological findings and their prognostic value in critical COVID-19 patients: An observational study.

Author(s) :

Niguet, Jean-Paul [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tortuyaux, Romain [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Garcia, Bruno [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jourdain, Mercedes [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Chaton, Laurence [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Preau, Sebastien [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Favory, Raphael [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Nseir, Saad [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Mathieu, Daniel [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Delval, Arnaud [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Derambure, Philippe [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Clinical Neurophysiology

Abbreviated title :

Clin Neurophysiol

Volume number :

132

Pages :

1009-1017

Publication date :

2021-03-22

ISSN :

1872-8952

English keyword(s) :

Electroencephalography
COVID-19
Encephalopathy
Neurophysiology
Evoked potentials

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Objective To describe EEG patterns of critical Coronavirus Disease 2019 (COVID-19) patients with suspicion of encephalopathy and test their association with clinical outcome. Methods EEG after discontinuation of ...
Show more >Objective To describe EEG patterns of critical Coronavirus Disease 2019 (COVID-19) patients with suspicion of encephalopathy and test their association with clinical outcome. Methods EEG after discontinuation of sedation in all patients, and somesthesic evoked potentials and brainstem auditive evoked potentials when EEG did not show reactivity, were performed. Clinical outcome was assessed at day 7 and 14 after neurophysiological explorations. Results 33 patients were included for analysis. We found slowed background activity in 85% of cases, unreactive activity in 42% of cases, low-voltage activity in 21% of cases and rhythmic or periodic delta waves in 61% of cases. EEG epileptic events were never recorded. Clinical outcome at day 14 was associated with unreactive background activity and tended to be associated with rhythmic or periodic delta waves and with low-voltage activity. Results of multimodal evoked potentials were in favor of a preservation of central nervous system somatosensory and auditory functions. Conclusions Among critical COVID-19 patients with abnormal arousal at discontinuation of sedation, EEG patterns consistent with encephalopathy are found and are predictive for short term clinical outcome. Significance The abnormal EEG with presence of periodic discharges and lack of reactivity could be related to encephalopathy linked to COVID-19.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Laboratoire de virologie - ULR 3610
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Recherche translationnelle sur le diabète (RTD) - U1190
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Submission date :

2024-01-17T22:16:09Z
2024-02-14T09:08:26Z