Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells.

Nekoua, Magloire Pandoua; Dechaumes, Arthur; Sane, Famara; Alidjinou, Enagnon Kazali; Moutairou, Kabirou; Yessoufou, Akadiri; Hober, Didier

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.3390/microorganisms8070989

PMID :

32630332

Permalink :

http://hdl.handle.net/20.500.12210/102846

Title :

Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells.

Author(s) :

Nekoua, Magloire Pandoua [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Dechaumes, Arthur [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alidjinou, Enagnon Kazali [Auteur]

Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Moutairou, Kabirou [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Yessoufou, Akadiri [Auteur]
Institut des Sciences Biomédicales Appliquées [ISBA]
Hober, Didier [Auteur]

Laboratoire de virologie - ULR 3610

Journal title :

Microorganisms

Abbreviated title :

Microorganisms

Volume number :

Pages :

989

Publication date :

2020-07-11

ISSN :

2076-2607

English keyword(s) :

enteroviruses
NK cells
HLA class I
persistence
type 1 diabetes

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Enteroviruses, especially group B coxsackieviruses (CV-B), have been associated with the development of chronic diseases such as type 1 diabetes (T1D). The pathological mechanisms that trigger virus-induced autoimmunity ...
Show more >Enteroviruses, especially group B coxsackieviruses (CV-B), have been associated with the development of chronic diseases such as type 1 diabetes (T1D). The pathological mechanisms that trigger virus-induced autoimmunity against islet antigens in T1D are not fully elucidated. Animal and human studies suggest that NK cells response to CV-B infection play a crucial role in the enteroviral pathogenesis of T1D. Indeed, CV-B-infected cells can escape from cytotoxic T cells recognition and destruction by inhibition of cell surface expression of HLA class I antigen through non-structural viral proteins, but they can nevertheless be killed by NK cells. Cytolytic activity of NK cells towards pancreatic beta cells persistently-infected with CV-B has been reported and defective viral clearance by NK cells of patients with T1D has been suggested as a mechanism leading to persistence of CV-B and triggering autoimmunity reported in these patients. The knowledge about host antiviral defense against CV-B infection is not only crucial to understand the susceptibility to virus-induced T1D but could also contribute to the design of new preventive or therapeutic approaches for individuals at risk for T1D or newly diagnosed patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:21:05Z
2024-02-08T08:33:35Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/102846*	2024-02-08T08:29:22Z
1	20.500.12210/102846.1	2024-01-17T22:21:05Z

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