Title :

Impact of coxsackievirus-B4E2 combined with a single low dose of streptozotocin on pancreas of outbred mice: investigation of viral load, pathology and inflammation.

Author(s) :

Benkahla, Mehdi A. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]
Laboratoire de virologie - ULR 3610
Bertin, Antoine [Auteur]
Laboratoire de virologie - ULR 3610
Vreulx, Anais-Camille [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Elmastour, Firas [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Jaidane, Hela [Auteur]
Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives [Monastir] [LR99ES27]
Desailloud, Rachel [Auteur]
CHU Amiens-Picardie
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610

Journal title :

Scientific Reports

Abbreviated title :

Sci Rep

Volume number :

9

Pages :

10080

Publication date :

2019-07-20

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Coxsackieviruses B (CV-B) belong to the EV-B species. CV-B and particularly CV-B4 are thought to be involved in the development of chronic diseases like type 1 diabetes (T1D). The mechanisms of the enteroviral pathogenesis ...
Show more >Coxsackieviruses B (CV-B) belong to the EV-B species. CV-B and particularly CV-B4 are thought to be involved in the development of chronic diseases like type 1 diabetes (T1D). The mechanisms of the enteroviral pathogenesis of T1D are not well known, yet. The in vitro studies are rich with information but in vivo infection models are needed to investigate the impact of viruses onto organs. Our objective was to study the impact of CV-B4E2 combined with a single sub-diabetogenic dose of streptozotocin (STZ) on the pancreas of mice. The infection with CV-B4E2 of CD1 outbred mice treated with a sub-diabetogenic dose of STZ induced hyperglycemia and hypoinsulinemia. Along with the chemokine IP-10, viral RNA and infectious particles were detected in the pancreas. The pancreas of these animals was also marked with insulitis and other histological alterations. The model combining STZ and CV-B4E2 opens the door to new perspectives to better understand the interactions between virus and host, and the role of environmental factors capable, like STZ, to predispose the host to the diabetogenic effects of enteroviruses.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:31:24Z
2024-02-12T10:10:33Z