Title :

Aqueous extracts of Syzygium brazzavillense can inhibit the infection with coxsackievirus B4 in vitro.

Author(s) :

Badia-Boungou, Francis [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Hennebelle, Thierry [Auteur]
BioEcoAgro - UMR-T 1158
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Roumy, Vincent [Auteur]
BioEcoAgro - UMR-T 1158
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Ngakegni-Limbili, Adolphe Christian [Auteur]
Nguimbi, Etienne [Auteur]
Moukassa, Donatien [Auteur]

Abena, Ange Antoine [Auteur]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610

Journal title :

Journal of Medical Virology

Abbreviated title :

J. Med. Virol.

Volume number :

91

Pages :

1210-1216

Publication date :

2019-02-23

ISSN :

1096-9071

English keyword(s) :

Republic of Congo
plant
enterovirus
aqueous extracts
antiviral activity

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Traditional practitioners commonly use plant crude extracts to treat various diseases in patients with symptoms that can be seen during enterovirus infections. In this study, the antienteroviral activity of medicinal plants ...
Show more >Traditional practitioners commonly use plant crude extracts to treat various diseases in patients with symptoms that can be seen during enterovirus infections. In this study, the antienteroviral activity of medicinal plants from the Republic of Congo has been evaluated in vitro. Through an ethnopharmacological approach, seven plants grouped into six families were identified. Aqueous and organic extracts of various organs from these plants were prepared. The organic extracts at subcytotoxic concentrations did not inhibit the cytopathic effect (CPE) induced by coxsackievirus (CV)B1-5, CVA6, poliovirus type 1, and enterovirus 71. The aqueous extract of Syzygium brazzavillense, but not those of other plants, inhibited the CPE induced by CVB3 and CVB4 at 30 µg/mL (CC50; 2800 µg/mL, IC50; 0.8 µg/mL) and by CVB2 and poliovirus type 1 at higher concentrations. When aqueous extract of this plant was mixed with CVB4, the replication of the virus was inhibited. In conclusion, aqueous extracts of Syzygium brazzavillense can inhibit the infection with CVB4 and other enteroviruses in vitro. The present ethnopharmacological investigation helped to identify a plant with potential properties useful to combat enterovirus infections.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• BioEcoAgro - UMR-T 1158
• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:33:08Z
2024-02-12T10:02:41Z