Fluoxetine can inhibit coxsackievirus-B4 ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Fluoxetine can inhibit coxsackievirus-B4 E2 in vitro and in vivo.
Auteur(s) :
Benkahla, Mehdi A. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Sane, Famara [Auteur]
Laboratoire de virologie - ULR 3610
Desailloud, Rachel [Auteur]
Université de Picardie Jules Verne [UPJV]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Sane, Famara [Auteur]
Laboratoire de virologie - ULR 3610
Desailloud, Rachel [Auteur]
Université de Picardie Jules Verne [UPJV]
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610
Titre de la revue :
Antiviral Research
Nom court de la revue :
Antiviral Res.
Numéro :
159
Pagination :
130-133
Date de publication :
2018-10-13
ISSN :
1872-9096
Mot(s)-clé(s) en anglais :
Enterovirus
Fluoxetine
Antiviral activity
Mouse model
In vitro
In vivo
Fluoxetine
Antiviral activity
Mouse model
In vitro
In vivo
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Group B Coxsackieviruses (CV-B) are responsible for various acute human diseases, and they are involved in chronic diseases such as type 1 diabetes. It has been reported that fluoxetine (FLX) inhibited CV-B4E2 in human ...
Lire la suite >Group B Coxsackieviruses (CV-B) are responsible for various acute human diseases, and they are involved in chronic diseases such as type 1 diabetes. It has been reported that fluoxetine (FLX) inhibited CV-B4E2 in human cell lines in vitro. In so far as CV-B4E2 can replicate in CD1 mice, it was investigated whether FLX could inhibit CV-B4E2 in vitro and in vivo in mouse systems. When 5.5 μM FLX was added to CV-B4E2-infected Min-6 cell (murine pancreas beta cell line) cultures, the virus-induced cytopathic effect was inhibited. In this system and in CV-B4E2-infected CD1 mouse pancreatic organotypic cultures treated with FLX the levels of infectious particles in supernatant fluids were below the limit of detection of the assay. The administration of FLX (10 mg/kg/day) by intraperitoneal route resulted in significant reduced levels of infectious particles in heart and pancreas of mice inoculated with CV-B4E2 by the same route. In conclusion FLX can inhibit CV-B4 in vitro and in vivo in mouse systems, additional studies are needed to investigate further the potential value of FLX to combat CV-B4 infections and to treat CV-B4-induced diseases.Lire moins >
Lire la suite >Group B Coxsackieviruses (CV-B) are responsible for various acute human diseases, and they are involved in chronic diseases such as type 1 diabetes. It has been reported that fluoxetine (FLX) inhibited CV-B4E2 in human cell lines in vitro. In so far as CV-B4E2 can replicate in CD1 mice, it was investigated whether FLX could inhibit CV-B4E2 in vitro and in vivo in mouse systems. When 5.5 μM FLX was added to CV-B4E2-infected Min-6 cell (murine pancreas beta cell line) cultures, the virus-induced cytopathic effect was inhibited. In this system and in CV-B4E2-infected CD1 mouse pancreatic organotypic cultures treated with FLX the levels of infectious particles in supernatant fluids were below the limit of detection of the assay. The administration of FLX (10 mg/kg/day) by intraperitoneal route resulted in significant reduced levels of infectious particles in heart and pancreas of mice inoculated with CV-B4E2 by the same route. In conclusion FLX can inhibit CV-B4 in vitro and in vivo in mouse systems, additional studies are needed to investigate further the potential value of FLX to combat CV-B4 infections and to treat CV-B4-induced diseases.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2024-01-17T22:49:40Z
2024-02-07T13:00:42Z
2024-02-07T13:00:42Z