Title :

Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo.

Author(s) :

Benkahla, Mehdi A. [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Elmastour, Firas [Auteur]
Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives [Monastir] [LR99ES27]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Sane, Famara [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Vreulx, Anais-Camille [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Engelmann, Ilka [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Desailloud, Rachel [Auteur]
Université de Picardie Jules Verne [UPJV]
Jaidane, Hela [Auteur]
Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives [Monastir] [LR99ES27]
Alidjinou, Enagnon Kazali [Auteur]
Laboratoire de virologie - ULR 3610
Hober, Didier [Auteur]
Laboratoire de virologie - ULR 3610

Journal title :

Virology

Abbreviated title :

Virology

Volume number :

522

Pages :

271-280

Publication date :

2018-08-11

ISSN :

1096-0341

English keyword(s) :

Bone marrow
Spleen
Serum
Mouse
Enterovirus

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Viral RNA (vRNA) is found in mice inoculated with coxsackievirus-B4E2 (CV-B4E2). The CV-B4E2 infection of murine spleen cells in vitro is enhanced with CV-B4E2-infected mouse serum. It has been investigated whether ...
Show more >Viral RNA (vRNA) is found in mice inoculated with coxsackievirus-B4E2 (CV-B4E2). The CV-B4E2 infection of murine spleen cells in vitro is enhanced with CV-B4E2-infected mouse serum. It has been investigated whether monocyte/macrophages were targets of CV-B4E2 in mice. vRNA has been detected in spleen and bone marrow of infected animals. The levels of vRNA were higher in CD14+ cells than in CD14- spleen cells and in F4/80- cells than in F4/80+ spleen cells. Meanwhile, CD14+ cells and F4/80- cells were more permissive to CV-B4E2 in vitro and the infection was enhanced when the virus was mixed with immune serum. While CV-B4E2 infected BMDM cultures (98% F4/80+); however, the immune serum did not enhance the infection. In conclusion, CV-B4E2 infects monocytes (CD14+, F4/80-) and macrophages (CD14+, F4/80+) in vivo and immune serum can enhance the in vitro infection of these cells arising out of the spleen.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610

Submission date :

2024-01-17T22:50:34Z
2024-02-14T09:14:02Z