Title :

Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory

Author(s) :

Tissot, Sophie [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Gérard, Anne-Lise [Auteur]
Deakin University [Waurn Ponds]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Boutry, Justine [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Dujon, Antoine [Auteur]
Deakin University [Waurn Ponds]
Russel, Tracey [Auteur]
The University of Sidney
Siddle, Hannah [Auteur]
University of Southampton
Tasiemski, Aurélie [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Hamede, Rodrigo [Auteur]
University of Tasmania [Hobart] [UTAS]
Meliani, Jordan [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Roche, Benjamin [Auteur]
Universidad Nacional Autónoma de México = National Autonomous University of Mexico [UNAM]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Ujvari, Beata [Auteur]
Deakin University [Waurn Ponds]
Thomas, Frédéric [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]

Journal title :

Pathogens

Pages :

241

Publisher :

MDPI

Publication date :

2022

ISSN :

2076-0817

English keyword(s) :

Ecology
Environmental factors
Evolution
Human activities
Transmissible cancers
Transmission

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Ecologie, Environnement/Santé
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses

English abstract : [en]

Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” ...
Show more >Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines.Show less >

Language :

Anglais

Popular science :

Non

ANR Project :

ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL