Titre :

The relationship between a new biomarker of vagal neuroimmuno-modulation and survival in two fatal cancers.

Auteur(s) :

Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
De Couck, M. [Auteur]
Schallier, D. [Auteur]
De greve, J. [Auteur]
Van Laethem, J-L. [Auteur]
Maréchal, R. [Auteur]

Titre de la revue :

Journal of Immunology Research

Pagination :

4874193

Date de publication :

2018-05-08

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

Background The vagus nerve may slow tumor progression because it inhibits inflammation. This study examined the relationship between a new vagal neuroimmunomodulation (NIM) index and survival in fatal cancers. Method We ...
Lire la suite >Background The vagus nerve may slow tumor progression because it inhibits inflammation. This study examined the relationship between a new vagal neuroimmunomodulation (NIM) index and survival in fatal cancers. Method We retroactively derived markers of vagal nerve activity indexed by heart rate variability (HRV), specifically the root mean square of successive differences (RMSSD), from patients' electrocardiograms near diagnosis. The NIM index was the ratio of RMSSD to C-reactive protein levels (RMSSD/CRP). Sample 1 included 202 Belgian patients with advanced pancreatic cancer (PC), while sample 2 included 71 Belgian patients with non-small cell lung cancer (NSCLC). In both samples, we examined the overall survival, while in sample 2, we additionally examined the survival time in deceased patients. Results In PC patients, in a multivariate Cox regression controlling for confounders, the NIM index had a protective relative risk (RR) of 0.68 and 95% confidence interval (95% CI) of 0.51–0.92. In NSCLC patients, the NIM index also had a protective RR of 0.53 and 95% CI of 0.32–0.88. Finally, in NSCLC, patients with a higher NIM index survived more days (475.2) than those with lower NIM (285.1) (p < 0.05). Conclusions The NIM index, reflecting vagal modulation of inflammation, may be a new independent prognostic biomarker in fatal cancers.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Dynamique Émotionnelle et Pathologies (DEEP)

Date de dépôt :

2024-01-18T11:02:05Z
2024-02-12T16:25:32Z