The Vagus Nerve Can Predict and Possibly ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
The Vagus Nerve Can Predict and Possibly Modulate Non-Communicable Chronic Diseases: Introducing a Neuroimmunological Paradigm to Public Health
Auteur(s) :
Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Deschepper, E. [Auteur]
De Couck, M. [Auteur]
Thaver, J-F. [Auteur]
Velkeniers, B. [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Deschepper, E. [Auteur]
De Couck, M. [Auteur]
Thaver, J-F. [Auteur]
Velkeniers, B. [Auteur]
Titre de la revue :
Journal of Clinical Medicine
Numéro :
7
Pagination :
p.371
Date de publication :
2018-10-19
Mot(s)-clé(s) en anglais :
global burden of diseases
neuroimmunology
neuromodulation
prediction
prevention
vagal nerve.
neuroimmunology
neuromodulation
prediction
prevention
vagal nerve.
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
Global burden of diseases (GBD) includes non-communicable conditions such as cardiovascular diseases, cancer and chronic obstructive pulmonary disease. These share important behavioral risk factors (e.g., smoking, diet) ...
Lire la suite >Global burden of diseases (GBD) includes non-communicable conditions such as cardiovascular diseases, cancer and chronic obstructive pulmonary disease. These share important behavioral risk factors (e.g., smoking, diet) and pathophysiological contributing factors (oxidative stress, inflammation and excessive sympathetic activity). This article wishes to introduce to medicine and public health a new paradigm to predict, understand, prevent and possibly treat such diseases based on the science of neuro-immunology and specifically by focusing on vagal neuro-modulation. Vagal nerve activity is related to frontal brain activity which regulates unhealthy lifestyle behaviors. Epidemiologically, high vagal activity, indexed by greater heart rate variability (HRV), independently predicts reduced risk of GBD and better prognosis in GBD. Biologically, the vagus nerve inhibits oxidative stress, inflammation and sympathetic activity (and associated hypoxia). Finally, current non-invasive methods exist to activate this nerve for neuro-modulation, and have promising clinical effects. Indeed, preliminary evidence exists for the beneficial effects of vagal nerve activation in diabetes, stroke, myocardial infarction and possibly cancer. Thus, we propose to routinely implement measurement of HRV to predict such GBD in populations, and to test in randomized controlled trials effects of non-invasive vagal nerve activation on prevention and treatment of GBD, reflecting possible neuro-modulation of health.Lire moins >
Lire la suite >Global burden of diseases (GBD) includes non-communicable conditions such as cardiovascular diseases, cancer and chronic obstructive pulmonary disease. These share important behavioral risk factors (e.g., smoking, diet) and pathophysiological contributing factors (oxidative stress, inflammation and excessive sympathetic activity). This article wishes to introduce to medicine and public health a new paradigm to predict, understand, prevent and possibly treat such diseases based on the science of neuro-immunology and specifically by focusing on vagal neuro-modulation. Vagal nerve activity is related to frontal brain activity which regulates unhealthy lifestyle behaviors. Epidemiologically, high vagal activity, indexed by greater heart rate variability (HRV), independently predicts reduced risk of GBD and better prognosis in GBD. Biologically, the vagus nerve inhibits oxidative stress, inflammation and sympathetic activity (and associated hypoxia). Finally, current non-invasive methods exist to activate this nerve for neuro-modulation, and have promising clinical effects. Indeed, preliminary evidence exists for the beneficial effects of vagal nerve activation in diabetes, stroke, myocardial infarction and possibly cancer. Thus, we propose to routinely implement measurement of HRV to predict such GBD in populations, and to test in randomized controlled trials effects of non-invasive vagal nerve activation on prevention and treatment of GBD, reflecting possible neuro-modulation of health.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Équipe(s) de recherche :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Date de dépôt :
2024-01-18T11:05:13Z
2024-02-12T13:20:16Z
2024-02-12T13:20:16Z
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