Therapeutic potential of the vagus nerve ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Therapeutic potential of the vagus nerve in cancer.
Author(s) :
Reimen, E. [Auteur]
De greve, J. [Auteur]
De Couck, J. [Auteur]
Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
De greve, J. [Auteur]
De Couck, J. [Auteur]
Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Journal title :
Immunology Letters
Volume number :
202
Pages :
p.38-43
Publication date :
2018-10
English keyword(s) :
Acetylcholine
Cancer immunity
Vagotomy
Vagus/vagal nerve.
Cancer immunity
Vagotomy
Vagus/vagal nerve.
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the ...
Show more >Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment. Also studies in pathologies other than cancer suggest a role for the vagus nerve in altering immunological responses relevant to anticancer immunity. These results provide a rationale to expect that vagus nerve stimulation, in combination with conventional cancer treatments, may improve the prognosis of cancer patients by promoting anticancer immunity.Show less >
Show more >Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment. Also studies in pathologies other than cancer suggest a role for the vagus nerve in altering immunological responses relevant to anticancer immunity. These results provide a rationale to expect that vagus nerve stimulation, in combination with conventional cancer treatments, may improve the prognosis of cancer patients by promoting anticancer immunity.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Submission date :
2024-01-18T11:08:19Z
2024-02-12T13:15:39Z
2024-02-12T13:15:39Z