Therapeutic potential of the vagus nerve ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
URL permanente :
Titre :
Therapeutic potential of the vagus nerve in cancer.
Auteur(s) :
Reimen, E. [Auteur]
De greve, J. [Auteur]
De Couck, J. [Auteur]
Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
De greve, J. [Auteur]
De Couck, J. [Auteur]
Gidron, Yori [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Titre de la revue :
Immunology Letters
Numéro :
202
Pagination :
p.38-43
Date de publication :
2018-10
Mot(s)-clé(s) en anglais :
Acetylcholine
Cancer immunity
Vagotomy
Vagus/vagal nerve.
Cancer immunity
Vagotomy
Vagus/vagal nerve.
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the ...
Lire la suite >Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment. Also studies in pathologies other than cancer suggest a role for the vagus nerve in altering immunological responses relevant to anticancer immunity. These results provide a rationale to expect that vagus nerve stimulation, in combination with conventional cancer treatments, may improve the prognosis of cancer patients by promoting anticancer immunity.Lire moins >
Lire la suite >Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment. Also studies in pathologies other than cancer suggest a role for the vagus nerve in altering immunological responses relevant to anticancer immunity. These results provide a rationale to expect that vagus nerve stimulation, in combination with conventional cancer treatments, may improve the prognosis of cancer patients by promoting anticancer immunity.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Équipe(s) de recherche :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Date de dépôt :
2024-01-18T11:08:19Z
2024-02-12T13:15:39Z
2024-02-12T13:15:39Z