Film Coatings Based on Aqueous Shellac ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Film Coatings Based on Aqueous Shellac Ammonium Salt \"Swanlac ® ASL 10\" and Inulin for Colon Targeting.
Auteur(s) :
Strich, Samuel [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Azehaf, H. [Auteur]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lellouche-Jacob, Y. [Auteur]
Medkour, N. [Auteur]
Penning, M. [Auteur]
Karrout, Youness [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Advanced Drug Delivery Systems (ADDS) - U1008
Azehaf, H. [Auteur]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lellouche-Jacob, Y. [Auteur]
Medkour, N. [Auteur]
Penning, M. [Auteur]
Karrout, Youness [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Titre de la revue :
AAPS PharmSciTech
Nom court de la revue :
AAPS PharmSciTech
Numéro :
24
Pagination :
205
Date de publication :
2023-10-12
ISSN :
1530-9932
Mot(s)-clé(s) en anglais :
aqueous shellac salt solution
colon targeting
film coatings
inulin
oral controlled release
reservoir systems
colon targeting
film coatings
inulin
oral controlled release
reservoir systems
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Over the past decades, increasing interests took place in the realm of drug delivery systems. Beyond treating intestinal diseases such as inflammatory bowel disease, colon targeting can provide possible applications for ...
Lire la suite >Over the past decades, increasing interests took place in the realm of drug delivery systems. Beyond treating intestinal diseases such as inflammatory bowel disease, colon targeting can provide possible applications for oral administration of proteins as well as vaccines due to the lower enzymatic activity in the distal part of GIT. To date, many strategies are employed to reach the colon. This article encompasses different biomaterials tested as film coatings and highlights appropriate formulations for colonic drug delivery. A comparison of different films was made to display the most interesting drug release profiles. These films contained ethylcellulose, as a thermoplastic polymer, blended with an aqueous shellac ammonium salt solution. Different blend ratios were selected as well for thin films as for coated mini-tablets, mainly varying as follows: (80:20); (75:25); (60:40). The impact of blend ratio and coating level was examined as well as the addition of natural polysaccharide “inulin” to target the colon. In vitro drug release was measured in 0.1 M HCl for 2 h followed by phosphate buffer saline pH 6.8 to simulate gastric and intestinal fluids, respectively. Coated mini-tablets were exposed to fresh fecal samples of humans in order to simulate roughly colonic content. Several formulations were able to fully protect theophylline as a model drug up to 8 h in the upper GIT, but allowing for prolonged release kinetics in the colon. These very interesting colonic release profiles were related to the amount of the natural polysaccharide added into the system.Lire moins >
Lire la suite >Over the past decades, increasing interests took place in the realm of drug delivery systems. Beyond treating intestinal diseases such as inflammatory bowel disease, colon targeting can provide possible applications for oral administration of proteins as well as vaccines due to the lower enzymatic activity in the distal part of GIT. To date, many strategies are employed to reach the colon. This article encompasses different biomaterials tested as film coatings and highlights appropriate formulations for colonic drug delivery. A comparison of different films was made to display the most interesting drug release profiles. These films contained ethylcellulose, as a thermoplastic polymer, blended with an aqueous shellac ammonium salt solution. Different blend ratios were selected as well for thin films as for coated mini-tablets, mainly varying as follows: (80:20); (75:25); (60:40). The impact of blend ratio and coating level was examined as well as the addition of natural polysaccharide “inulin” to target the colon. In vitro drug release was measured in 0.1 M HCl for 2 h followed by phosphate buffer saline pH 6.8 to simulate gastric and intestinal fluids, respectively. Coated mini-tablets were exposed to fresh fecal samples of humans in order to simulate roughly colonic content. Several formulations were able to fully protect theophylline as a model drug up to 8 h in the upper GIT, but allowing for prolonged release kinetics in the colon. These very interesting colonic release profiles were related to the amount of the natural polysaccharide added into the system.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2024-01-19T22:02:38Z
2024-01-29T16:04:46Z
2024-04-02T07:44:46Z
2024-04-02T13:35:49Z
2024-04-29T07:59:45Z
2024-01-29T16:04:46Z
2024-04-02T07:44:46Z
2024-04-02T13:35:49Z
2024-04-29T07:59:45Z
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