Title :

Advanced age does not increase morbidity after total thyroidectomy. Result of a prospective study.

Author(s) :

Christou, N. [Auteur]
Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges]
Blanchard, C. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Volteau, C. [Auteur]
Brunaud, L. [Auteur]
Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy]
Hamy, Antoine [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Dahan, M. [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Prades, J. M. [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Landecy, G. [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Dernis, H. P. [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Lifante, J. C. [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Sebag, F. [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Jegoux, F. [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Babin, E. [Auteur]
CHU Caen
Bizon, A. [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Caillard, C. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Mathonnet, M. [Auteur]
Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges]
Mirallié, E. [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]

Journal title :

American Journal of Surgery

Abbreviated title :

Am. J. Surg.

Volume number :

217

Pages :

p. 767-771

Publication date :

2019-08

ISSN :

1879-1883

English keyword(s) :

Age
Thyroidectomy
Morbidity
Safety

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background It is well known that total thyroidectomy is feasible on elderly patients but is linked to complications because of their underlying comorbidities. In this study we analyzed the specific risks linked to surgery, ...
Show more >Background It is well known that total thyroidectomy is feasible on elderly patients but is linked to complications because of their underlying comorbidities. In this study we analyzed the specific risks linked to surgery, hypoparathyroidism and recurrent nerve palsy. Methods materials-methods:Prospective, multicentre trial conducted at 13 hospital sites. The primary endpoint was the percentage of patients with postoperative hypocalcaemia (albumin-corrected serum calcium level <2 mmol/L at day 2). Secondary endpoints included recurrent nerve palsy rate at day 2, the percentage of patients with hypocalcaemia (serum calcium level <2 mmol/L) and recurrent nerve palsy at month 6, operating durations and postoperative pain. Patients were separated in two groups: <70 years and ≥70 years old. Results In total, 1329 patients who underwent total thyroidectomy were included (median age 51.17 years [18.10; 80.90], 80% women, and hyperthyroidism in 20%, 101 ≥ 70 years old). Rates of hypocalcaemia at day 2 and month 6 were 20.02% and 1.98% respectively. Nasofibroscopy showed postoperative abnormal vocal cord motility in 9.92% cases (hypo-motility 5.76% - immobility 4.16%) and 0.95% at month 6 (hypo-motility 0.48%, immobility 0.48%). Patients ≥70 years had a lower (but non-significant) postoperative and definitive hypocalcaemia rate than patients < 70 years: 14.85% vs 20.44% at day 2 (p = 0.1773) and 0% vs 2.15% at month 6 respectively (p = 0.2557). Abnormal vocal cord motility rate was 12.00% in patients ≥70 years vs 9.75% in patients <70 years at day 2 (p = 0.4702), and 2.06% in patients ≥70 years vs 0.86% at month 6 (p = 0.2340). Conclusions Total thyroidectomy in patients ≥70 years is feasible and safe. Age does not increase the morbidity. The study is registered with ClinicalTrials.gov number NCT01551914.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-19T23:58:44Z
2024-10-03T09:26:49Z