Title :

Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: the EPIPAGE-2 study.

Author(s) :

Boileau, Pascal [Auteur]
CHI Poissy-Saint-Germain
Letouzey, Mathilde [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
CHI Poissy-Saint-Germain
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Morgan, Andrei S. [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
University College of London [London] [UCL]
Lorthe, Elsa [Auteur]
Geneva University Hospitals and Geneva University
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Kaminski, Monique [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Coquelin, Anaëlle [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Azria, Elie [Auteur]
Centre hospitalier Saint-Joseph [Paris]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Caeymaex, Laurence [Auteur]
CHI Créteil
Rouget, Florence [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Diguisto, Caroline [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Claris, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Tosello, Barthélémy [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Truffert, Patrick [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bétrémieux, Pierre [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Benhammou, Valérie [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Marchand-Martin, Laetitia [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Goffinet, François [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Ancel, Pierre-Yves [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Foix-L'hélias, Laurence [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
CHU Trousseau [APHP]

Journal title :

Acta Paediatrica

Abbreviated title :

Acta Paediatr

Publication date :

2023-07-10

ISSN :

1651-2227

English keyword(s) :

cause of death
extremely preterm infants
end of life decision
preterm birth
withdrawal

English abstract : [en]

Aim To describe the circumstances, causes and timing of death in extremely preterm infants. Methods We included from the EPIPAGE-2 study infants born at 24–26 weeks in 2011 admitted to neonatal intensive care units ...
Show more >Aim To describe the circumstances, causes and timing of death in extremely preterm infants. Methods We included from the EPIPAGE-2 study infants born at 24–26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants: alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST). The main cause of death was classified as respiratory disease, necrotizing enterocolitis, infection, central nervous system (CNS) injury, other or unknown. Results Among 768 infants admitted to NICU, 224 died among which 89 died without WWLST and 135 with WWLST. The main causes of death were respiratory disease (38%), CNS injury (30%) and infection (12%). Among the infants who died with WWLST, CNS injury was the main cause of death (47%), whereas respiratory disease (56%) and infection (20%) were the main causes in case of death without WWLST. Half (51%) of all deaths occurred within the first 7 days of life, and 35% occurred within 8 and 28 days. Conclusion The death of extremely preterm infants in NICU is a complex phenomenon in which the circumstances and causes of death are intertwined.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2024-01-20T22:12:18Z
2024-04-08T13:18:22Z