Title :

Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author(s) :

Gonzalez-Gil, E.M [Auteur]
Cadenas-Sanchez, Cristina [Auteur]
Santabarbara, Javier [Auteur]
Bueno-Lozano, G [Auteur]
Iglesia, Iris [Auteur]
Gonzalez-Gross, Marcela [Auteur]
Molnar, Denes [Auteur]
Gottrand, fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
De Henauw, Stefaan [Auteur]
Kafatos, Anthony [Auteur]
Widhalm, Kurt [Auteur]
Manios, Yannis [Auteur]
Siani, Alfonso [Auteur]
Amaro-Gahete, F [Auteur]
Ruperez A., I [Auteur]
Canada, David [Auteur]
Censi, Laura [Auteur]
Kersting, Mathilde [Auteur]
Dallongeville, Jean [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Marcos, Ascension [Auteur]
Ortega, F.B [Auteur]
Moreno, L.A [Auteur]

Journal title :

Nutrition, Metabolism and Cardiovascular Diseases

Abbreviated title :

Nutr. Metab. Carbiovasc. Dis.

Volume number :

28

Pages :

77-83

Publisher :

Elsevier

Publication date :

2018-01

ISSN :

0939-4753

Keyword(s) :

Inflammation
Inflammatory biomarkers
adolescents
Metabolic syndrome
Metabolic health

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and aims: Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) ...
Show more >Background and aims: Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results: A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results : Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions: Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:35:15Z
2021-06-02T10:05:32Z
2024-01-24T13:35:46Z