Combined alcoholic and non-alcoholic steatohepatitis

Ntandja Wandji, Line; Gnemmi, Viviane; Mathurin, Philippe; Louvet, Alexandre

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.jhepr.2020.100101

PMID :

32514497

Title :

Combined alcoholic and non-alcoholic steatohepatitis

Author(s) :

Ntandja Wandji, Line [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gnemmi, Viviane [Auteur]

Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Mathurin, Philippe [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

JHEP Reports Innovation in Hepatology

Pages :

100101

Publisher :

Elsevier

Publication date :

2020-06-01

Keyword(s) :

diabetes
obesity
metabolic syndrome
NAFLD
NASH
ASH
Alcohol
ALD

English keyword(s) :

Alcohol
ALD
ASH
NASH
NAFLD
metabolic syndrome
obesity
diabetes

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown ...
Show more >While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL

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