Combined alcoholic and non-alcoholic ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Title :
Combined alcoholic and non-alcoholic steatohepatitis
Author(s) :
Ntandja Wandji, Line [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gnemmi, Viviane [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gnemmi, Viviane [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
JHEP Reports Innovation in Hepatology
Pages :
100101
Publisher :
Elsevier
Publication date :
2020-06-01
Keyword(s) :
diabetes
obesity
metabolic syndrome
NAFLD
NASH
ASH
Alcohol
ALD
obesity
metabolic syndrome
NAFLD
NASH
ASH
Alcohol
ALD
English keyword(s) :
Alcohol
ALD
ASH
NASH
NAFLD
metabolic syndrome
obesity
diabetes
ALD
ASH
NASH
NAFLD
metabolic syndrome
obesity
diabetes
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown ...
Show more >While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.Show less >
Show more >While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Source :
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