Combined alcoholic and non-alcoholic steatohepatitis

Ntandja Wandji, Line; Gnemmi, Viviane; Mathurin, Philippe; Louvet, Alexandre

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.jhepr.2020.100101

PMID :

32514497

Titre :

Combined alcoholic and non-alcoholic steatohepatitis

Auteur(s) :

Ntandja Wandji, Line [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gnemmi, Viviane [Auteur]

Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Mathurin, Philippe [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]

Titre de la revue :

JHEP Reports Innovation in Hepatology

Pagination :

100101

Éditeur :

Elsevier

Date de publication :

2020-06-01

Mot(s)-clé(s) :

diabetes
obesity
metabolic syndrome
NAFLD
NASH
ASH
Alcohol
ALD

Mot(s)-clé(s) en anglais :

Alcohol
ALD
ASH
NASH
NAFLD
metabolic syndrome
obesity
diabetes

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown ...
Lire la suite >While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL

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