Title :

Difference in the cellular response following THP-1 derived phagocytic monocyte cells exposure to commercial aluminum-based adjuvants and aluminum-containing vaccines.

Author(s) :

Badran, Ghidaa [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Grare, Celine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Masson, Jean-Daniel [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
David, Marie-Odile [Auteur]
Structure et activité des biomolécules normales et pathologiques [SABNP]
Achour, Djamal [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Lo-Guidice, Jean-Marc [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Garçon, Guillaume [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Crépeaux, Guillemette [Auteur]
École nationale vétérinaire d'Alfort [ENVA]
Institut Mondor de Recherche Biomédicale [IMRB]

Journal title :

Journal of Trace Elements in Medicine and Biology

Abbreviated title :

J Trace Elem Med Biol

Volume number :

83

Pages :

127394

Publication date :

2024-01-25

ISSN :

1878-3252

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Aluminum-based adjuvants (ABAs) enhance the immune response following vaccine injection. Their mechanisms of action are not fully understood, and their bio-persistency have been described associated with ...
Show more >Background Aluminum-based adjuvants (ABAs) enhance the immune response following vaccine injection. Their mechanisms of action are not fully understood, and their bio-persistency have been described associated with long-term adverse effects. Methods We evaluated and compared the cellular effects of the two main ABAs and whole vaccines on ATP production, ROS generation and cytokines production (IL-6 and IL-10), using THP-1 cells. Results ABAs altered the cell energy metabolism by increasing ROS production after 24 h and reducing ATP production after 48 h. In addition, both ABAs and whole vaccines induced different kinetics of IL-6 production, whereas only ABAs induced IL-10 secretion. Conclusion This study showed clearly, for a first time, a difference in cellular response to the ABAs and whole vaccines which should be taken into consideration in future studies focusing on the effect of ABA in vaccines. Future studies on ABAs should also pay attention to mitochondrial function alterations following exposure to ABA-containing vaccines.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2024-01-26T22:00:48Z
2024-02-29T14:42:57Z