Title :

Post-operative complications in elderly onset inflammatory bowel disease: a population-based study

Author(s) :

Sacleux, S.-C. [Auteur]
Sarter, Helene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Fumery, Mathurin [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Charpentier, Cloe [Auteur]
Guillon, Nathalie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Coevoet, H. [Auteur]
Pariente, Benjamin [Auteur]
Hôpital Claude Huriez [Lille]
Peyrin-Biroulet, Laurent [Auteur]
Gower, Corinne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Savoye, Guillaume [Auteur]

Journal title :

Alimentary pharmacology & therapeutics

Abbreviated title :

Aliment. Pharmacol. Ther.

Volume number :

47

Pages :

1652-1660

Publication date :

2018-06

ISSN :

1365-2036

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce. To describe the incidence of and factors associated with post-operative complications in elderly onset ...
Show more >IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce. To describe the incidence of and factors associated with post-operative complications in elderly onset IBD, diagnosed after the age of 60. Using EPIMAD Cohort (1988-2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC). After a median post-operative follow-up of 6 years (2-10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post-operative days, the mortality rate was 4%. Thirty-two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post-operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty-seven long-term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15-28.52]) and emergency surgery (OR = 4.46 [1.75-11.36]) were associated with early post-operative complications, and (2) Female gender (HR = 2.10 [1.01-4.37]) and delay before surgery >3 months (HR = 2.09 [1.01-4.31]) with long-term adverse effects of surgical therapy. One-third of elderly IBD patients experienced at least 1 post-operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post-operative complication.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:26:32Z
2024-03-07T13:12:01Z