When to transplant a patient with alcoholic liver disease?

Document type :

Article dans une revue scientifique: Article original

PMID :

Permalink :

http://hdl.handle.net/20.500.12210/104829

Title :

When to transplant a patient with alcoholic liver disease?

Author(s) :

Dharancy, Sebastien [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Revue du Praticien (La)

Abbreviated title :

Rev Prat

Volume number :

68

Pages :

761-765

Publication date :

2018-09

ISSN :

0035-2640

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

When to transplant a patient with alcoholic liver disease? Alcoholic liver disease is the leading cause of cirrhosis in France, but there is only a minority of patients who have access to liver transplantation. Although ...
Show more >When to transplant a patient with alcoholic liver disease? Alcoholic liver disease is the leading cause of cirrhosis in France, but there is only a minority of patients who have access to liver transplantation. Although still controversial, this disease is a validated indication of liver transplantation with survival similar to that of other indications. The survival benefit of transplantation is limited to patients with severe decompensation. A period of abstinence is essential before accessing to the waiting list, but the 6-month abstinence rule is not a strong criterion for predicting the recurrent alcohol consumption after transplantation. In the future, an indication of liver transplantation may be punctually made in case by-case basis in case of steroid-resistant alcoholic hepatitis. The spectrum of post-transplant relapse is a heterogeneous continuum starting with low-level point real consumption, which has little impact on patient and graft survival, up to massive consumption which substantially decreases patient long-term survival. Only a minority of patients experience massive relapse after transplantation. The prevention of relapse need an early addictive specialized management that must begin before the liver transplantation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:26:59Z
2024-03-13T11:53:02Z

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