Title :

Allogeneic stem cell transplantation using hla-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the acute leukemia working party of the ebmt

Author(s) :

Poire, Xavier [Auteur]
Labopin, Myriam [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Polge, Emmanuelle [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Forcade, Edouard [Auteur]
Ganser, Arnold [Auteur]
Volin, Liisa [Auteur]
Michallet, Mauricette [Auteur]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Maertens, Johan [Auteur]
Richard Espiga, Carlos [Auteur]
Cornelissen, Jan J. [Auteur]
Finke, Jurgen [Auteur]
Mohty, Mohamad [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Esteve, Jordi [Auteur]
Nagler, Arnon [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]

Journal title :

Haematologica

Abbreviated title :

Haematologica

Volume number :

105

Publication date :

2019-02-01

ISSN :

1592-8721

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk ...
Show more >Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:01Z
2024-01-30T15:26:45Z