Systemic lupus erythematosus in native ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Systemic lupus erythematosus in native sub-saharan africans: a systematic review and meta-analysis
Author(s) :
Essouma, Mickael [Auteur]
University of Yaoundé [Cameroun]
Nkeck, Jan Rene [Auteur]
University of Yaoundé [Cameroun]
Endomba, Francky Teddy [Auteur]
Université de Bourgogne [UB]
Bigna, Jean Joel [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Singwe-Ngandeu, Madeleine [Auteur]
University of Yaoundé [Cameroun]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
University of Yaoundé [Cameroun]
Nkeck, Jan Rene [Auteur]
University of Yaoundé [Cameroun]
Endomba, Francky Teddy [Auteur]
Université de Bourgogne [UB]
Bigna, Jean Joel [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Singwe-Ngandeu, Madeleine [Auteur]
University of Yaoundé [Cameroun]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
Journal of Autoimmunity
Abbreviated title :
J. Autoimmun.
Volume number :
106
Publication date :
2020-01
ISSN :
1095-9157
English keyword(s) :
Systemic lupus erythematous
Native sub-Saharan Africans
Native sub-Saharan Africans
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The prevalence and phenotype of systemic lupus erythematosus (SLE) have not been thoroughly investigated in Native sub-Saharan Africans despite knowledge that the highest burden of SLE occurs in people with an African ...
Show more >The prevalence and phenotype of systemic lupus erythematosus (SLE) have not been thoroughly investigated in Native sub-Saharan Africans despite knowledge that the highest burden of SLE occurs in people with an African trait. Through this systematic review of literature and meta-analysis, we wished to fill this gap. PubMed, EMBASE, Web of Science, African Journals Online, and Global Index Medicus as well as references of retrieved papers were searched to select studies addressing SLE in Native sub-Saharan Africans and published between January 1, 2008 and October 7, 2018. The prevalence of SLE and its characteristics were pooled through narrative review and random-effects model. Heterogeneity (I22 Out of 1502 papers, 15 hospital-based studies were included. The pooled prevalence of SLE among 28,575 participants was 1.7% (0.8-2.9), with substantial heterogeneity between studies (I2 Over the last 30 years, SLE was not rare among Native sub-Saharan Africans and its featured characteristics were earlier onset, female predominance, and high seropositivity for extractable nuclear antigen autoantibodies. Corticosteroids and antimalarials were the standard treatments. The mortality rate was high. Population prevalence and incidence as well as full description of SLE characteristics in Native sub-Saharan Africans are needed.Show less >
Show more >The prevalence and phenotype of systemic lupus erythematosus (SLE) have not been thoroughly investigated in Native sub-Saharan Africans despite knowledge that the highest burden of SLE occurs in people with an African trait. Through this systematic review of literature and meta-analysis, we wished to fill this gap. PubMed, EMBASE, Web of Science, African Journals Online, and Global Index Medicus as well as references of retrieved papers were searched to select studies addressing SLE in Native sub-Saharan Africans and published between January 1, 2008 and October 7, 2018. The prevalence of SLE and its characteristics were pooled through narrative review and random-effects model. Heterogeneity (I22 Out of 1502 papers, 15 hospital-based studies were included. The pooled prevalence of SLE among 28,575 participants was 1.7% (0.8-2.9), with substantial heterogeneity between studies (I2 Over the last 30 years, SLE was not rare among Native sub-Saharan Africans and its featured characteristics were earlier onset, female predominance, and high seropositivity for extractable nuclear antigen autoantibodies. Corticosteroids and antimalarials were the standard treatments. The mortality rate was high. Population prevalence and incidence as well as full description of SLE characteristics in Native sub-Saharan Africans are needed.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2024-01-30T10:27:30Z
2024-03-27T13:52:39Z
2024-03-27T13:52:39Z