Title :

Influence of donor type, stem cell source and conditioning on outcomes after haploidentical transplant for lymphoma - a lwp-ebmt study

Author(s) :

Bazarbachi, Ali [Auteur]
Boumendil, Ariane [Auteur]
Finel, Herve [Auteur]
Castagna, Luca [Auteur]
Dominietto, Alida [Auteur]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Diez-Martin, Jose L. [Auteur]
Tischer, Johanna [Auteur]
Gulbas, Zafer [Auteur]
Wallet, Helene L. [Auteur]
Corral, Lucia L. [Auteur]
Mohty, Mohamad [Auteur]
Koc, Yener [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Schmid, Christoph [Auteur]
El Cheikh, Jean [Auteur]
Arat, Mutlu [Auteur]
Forcade, Edouard [Auteur]
Dreger, Peter [Auteur]
Rocha, Vanderson [Auteur]
Garcia, Gonzalo G. [Auteur]
Chalandon, Yves [Auteur]
Ferra, Christelle [Auteur]
Orvain, Corentin [Auteur]
Robinson, Stephen [Auteur]
Montoto, Silvia [Auteur]
Sureda, Anna [Auteur]

Journal title :

British Journal of Haematology

Abbreviated title :

Br. J. Haematol.

Volume number :

188

Pages :

745-756

Publication date :

2020-03

ISSN :

1365-2141

English keyword(s) :

donor type
lymphoma
stem cell source
conditioning
haploidentical transplant

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Haploidentical stem cell transplantation (haploSCT) is becoming a major transplant modality for lymphoma. To assess the effects of donor characteristics, stem cell source and conditioning on outcomes, we identified 474 ...
Show more >Haploidentical stem cell transplantation (haploSCT) is becoming a major transplant modality for lymphoma. To assess the effects of donor characteristics, stem cell source and conditioning on outcomes, we identified 474 adults with Hodgkin (HL; 240), peripheral T-cell (PTCL; 88), diffuse large B-cell (77), mantle cell (40) or follicular lymphoma (FL; 29), who received haploSCT with post-transplant cyclophosphamide. Median follow-up of alive patients was 32 months. On multivariate analysis, acute graft-versus-host disease (GVHD) grade 2-4 was lower with offspring donors or bone marrow cells, whereas extensive chronic GVHD was higher in partial response at haploSCT or when using sisters, haploidentical donors beyond first degree, or female donors in male patients. Progression-free survival (PFS) was better for FL, HL and PTCL, whereas overall survival (OS) was better for HL and PTCL. Complete remission at haploSCT improved PFS and OS whereas these were negatively affected by cytomegalovirus donor positive/recipient positive status. No other donor characteristics (age, gender, human leucocyte antigen mismatch, ABO incompatibility) affected PFS or OS except use of haploidentical donors beyond first degree, which negatively affected OS. PFS and OS are mostly influenced by disease status and lymphoma subtype, supporting the use of any first degree haploidentical family member as a donor.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:57Z
2024-01-31T13:53:27Z