Radiological assessment of mandibular ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Radiological assessment of mandibular invasion in squamous cell carcinoma of the oral cavity and oropharynx
Author(s) :
Bouhir, S. [Auteur]
Université de Lille
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Dubrulle-Berthelot, F. [Auteur]
Université de Lille
Leroy, Xavier [Auteur]
Université de Lille
Deken-Delannoy, V. [Auteur]
Université de Lille
Rysman, Benedicte [Auteur]
Université de Lille
Chevalier, Dominique [Auteur]
Université de Lille
Mouawad, Francois [Auteur]
Université de Lille
Université de Lille
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Dubrulle-Berthelot, F. [Auteur]
Université de Lille
Leroy, Xavier [Auteur]
Université de Lille
Deken-Delannoy, V. [Auteur]
Université de Lille
Rysman, Benedicte [Auteur]
Université de Lille
Chevalier, Dominique [Auteur]
Université de Lille
Mouawad, Francois [Auteur]
Université de Lille
Journal title :
European Annals of Otorhinolaryngology, Head and Neck Diseases
Abbreviated title :
Eur Ann Otorhinolaryngol Head Neck Dis
Volume number :
136
Pages :
361-366
Publication date :
2019-10
ISSN :
1879-730X
English keyword(s) :
Magnetic resonance imaging
Sensitivity and specificity
Computed tomography
Oropharyngeal and oral cavity cancer
Mandibular bone invasion
Sensitivity and specificity
Computed tomography
Oropharyngeal and oral cavity cancer
Mandibular bone invasion
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the ...
Show more >BACKGROUND: Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion. METHODS: A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx. RESULTS: Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49-0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion. CONCLUSIONS: CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.Show less >
Show more >BACKGROUND: Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion. METHODS: A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx. RESULTS: Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49-0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion. CONCLUSIONS: CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Submission date :
2024-01-30T10:27:58Z
2024-02-15T12:28:57Z
2024-02-15T12:28:57Z
Files
- document
- Open access
- Access the document