Title :

Radiological assessment of mandibular invasion in squamous cell carcinoma of the oral cavity and oropharynx

Author(s) :

Bouhir, S. [Auteur]
Université de Lille
Mortuaire, Geoffrey [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Dubrulle-Berthelot, F. [Auteur]
Université de Lille
Leroy, Xavier [Auteur]
Université de Lille
Deken-Delannoy, V. [Auteur]
Université de Lille
Rysman, Benedicte [Auteur]
Université de Lille
Chevalier, Dominique [Auteur]
Université de Lille
Mouawad, Francois [Auteur]
Université de Lille

Journal title :

European Annals of Otorhinolaryngology, Head and Neck Diseases

Abbreviated title :

Eur Ann Otorhinolaryngol Head Neck Dis

Volume number :

136

Pages :

361-366

Publication date :

2019-10

ISSN :

1879-730X

English keyword(s) :

Magnetic resonance imaging
Sensitivity and specificity
Computed tomography
Oropharyngeal and oral cavity cancer
Mandibular bone invasion

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the ...
Show more >BACKGROUND: Preoperative assessment of mandibular bone invasion in squamous cell carcinoma of the oral cavity and oropharynx is crucial for optimizing bone resection. The principal aim of this study was to evaluate the diagnostic value of CT and MR imaging for the diagnosis of mandibular bone invasion compared to the histological reference. In addition, we assessed the survival impact of bone invasion. METHODS: A single-center retrospective study included all consecutive patients treated by mandibular bone interruption for squamous cell carcinoma of the oral cavity and/or oropharynx. RESULTS: Sixty-eight patients were included. Prevalence of bone invasion on histology was 43%. Sensitivity, specificity and positive and negative predictive value were respectively 70%, 71%, 66% and 76% for CT compared with histologic analysis, 83%, 50%, 59% and 78% for MRI, and 83%, 62% 62%, 83% for associated CT and MRI. The two tests showed good agreement, with kappa index 0.69 (95% CI, 0.49-0.89) (P<0.0001). There was no difference in overall survival (log-rank>0.70) between the groups with and without bone invasion. CONCLUSIONS: CT and MRI are complementary for preoperative assessment of mandibular bone invasion, be it cortical and/or medullary, and in some cases may allow mandibular bone-sparing.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:27:58Z
2024-02-15T12:28:57Z