Atopic dermatitis in elderly adults

Dezoteux, Frédéric; Astrid, Bellissen; Chuffard, Marie; Drumez, Elodie; Azib, Selma; Staumont, delphine

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1684/ejd.2019.3609

PMID :

31486404

Permalink :

http://hdl.handle.net/20.500.12210/104967

Title :

Atopic dermatitis in elderly adults

Author(s) :

Dezoteux, Frédéric [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Astrid, Bellissen [Auteur]
Chuffard, Marie [Auteur]
Drumez, Elodie [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Azib, Selma [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Staumont, delphine [Auteur]

Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011

Journal title :

European Journal of Dermatology

Abbreviated title :

Eur J Dermatol

Volume number :

Pages :

371-374

Publisher :

John Libbey Eurotext

Publication date :

2019-09-04

ISSN :

1167-1122

English keyword(s) :

adults
atopic dermatitis
cyclosporine A

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Atopic dermatitis (AD) in adults over 45 years of age (AD≥45) has been poorly studied. OBJECTIVE: To determine whether the AD phenotype varies according to the pattern of AD onset in AD≥45 patients and whether ...
Show more >BACKGROUND: Atopic dermatitis (AD) in adults over 45 years of age (AD≥45) has been poorly studied. OBJECTIVE: To determine whether the AD phenotype varies according to the pattern of AD onset in AD≥45 patients and whether response to cyclosporine A (CsA) is influenced by age. METHODS: This monocentric retrospective study was performed in a French university department of dermatology. We included 409 AD<45 patients (111 treated with CsA) and 124 AD≥45 patients (26 treated with CsA). Among AD≥45 patients, 20% were categorised into Subgroup 1 (persistence of AD since childhood), 52% into Subgroup 2 (recurrence of AD with a history of classic childhood AD), and 28% into Subgroup 3 (adult-onset AD). RESULTS: Gender, associated atopic comorbidities, a family history of atopy, and AD severity were similar regarding the different patterns of AD onset in AD≥45 patients. Skin lesions predominated on the face and neck in AD≥45 patients with AD since childhood (30% in Subgroups 1 and 2) compared to those with adult-onset AD (14% in Subgroup 3). The efficacy of CsA was similar between groups AD≥45 and AD<45, but 28% of AD≥45 patients versus 20% of AD<45 patients had increased serum creatinine levels under CsA. CONCLUSIONS: No significant association seems to exist between the onset of AD and demographic or clinical characteristics in AD≥45 patients (except that head and neck involvement is rarer in adult-onset AD). Patient age does not influence response to CsA, but this drug appears to be less well tolerated in older patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

Submission date :

2024-01-30T10:28:01Z
2024-03-27T08:18:08Z

Version	Link	Modification date
2	20.500.12210/104967*	2024-03-27T08:12:22Z
1	20.500.12210/104967.1	2024-01-30T10:28:01Z

Atopic dermatitis in elderly adults

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Atopic dermatitis in elderly adults

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