Title :

Radiological response is associated with better outcomes and should be considered a therapeutic target in crohn''s disease

Author(s) :

Halle, Eleonore [Auteur]
Azahaf, Mustapha [Auteur]
Duveau, Nicolas [Auteur]
Lambin, Thomas [Auteur]
Nachury, Maria [Auteur]
Branche, Julien [Auteur]
Gerard, Romain [Auteur]
Lauriot Dit Prevost, Clementine [Auteur]
Kerbage, Pauline [Auteur]
Desreumaux, Pierre [Auteur]
Ernst, Olivier [Auteur]
Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189
Pariente, Benjamin [Auteur]

Journal title :

Digestive diseases and sciences

Abbreviated title :

Dig. Dis. Sci.

Publication date :

2019-12-06

ISSN :

1573-2568

English keyword(s) :

Disease complications
Transmural healing
Magnetic resonance enterography
Crohn's disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The aim of the study was to identify factors associated with a radiological response and to assess the impact of radiological improvement in long-term outcomes in small bowel (SB) Crohn's disease (CD) patients. We performed ...
Show more >The aim of the study was to identify factors associated with a radiological response and to assess the impact of radiological improvement in long-term outcomes in small bowel (SB) Crohn's disease (CD) patients. We performed a retrospective study from June 2011 to June 2017 in the tertiary center, Claude Huriez Hospital in Lille, France. All SB CD patients, who underwent two magnetic resonance enterographies (MRE) 3-12 months apart, with at least 1-year follow-up after the second MRE, were included. Signs of radiological inflammation were identified by two expert radiologists in CD. Patients were classified as radiological responders (RR) and non-responders (NR). Hospitalization rates, adjustment of treatment, and surgical or endoscopic interventions were assessed and compared between RR and NR. Factors associated with a radiological response were also studied using the Cox model. One hundred and fifteen SB CD patients were included with a median follow-up of 17 months (IQR 11.6-28.3). There were 54 (47%) RR and 61 (53%) NR. The risk of surgical or endoscopic intervention was higher in NR than RR (p = 0.04), and the median delay until a surgical or endoscopic intervention was shorter in NR (p = 0.04). Multifocal disease, a hypersignal on diffusion-weighted or dynamic contrast-enhanced imaging, a stricture, or a fistula was significantly associated with a decreased probability of a radiological response (p < 0.05). This study shows that a radiological response is associated with a decreased risk of surgical or endoscopic intervention and should be considered as a therapeutic target in CD patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Submission date :

2024-01-30T10:28:32Z