Title :

Spectrum and prognosis of anca-associated vasculitis-related bronchiectasis: data from 61 patients

Author(s) :

Lhote, Raphael [Auteur]
Chilles, Marie [Auteur]
Groh, Matthieu [Auteur]
Puechal, Xavier [Auteur]
Guilpain, Philippe [Auteur]
Ackermann, Felix [Auteur]
Amoura, Zahir [Auteur]
Annesi-Maesano, Isabella [Auteur]
Barba, Thomas [Auteur]
Catherinot, Emilie [Auteur]
Cohen-Aubart, Fleur [Auteur]
Cohen, Pascal [Auteur]
Cottin, Vincent [Auteur]
Couderc, Louis-Jean [Auteur]
De Boysson, Hubert [Auteur]
Delbrel, Xavier [Auteur]
Dominique, Stephane [Auteur]
Duhaut, Pierre [Auteur]
Fain, Olivier [Auteur]
Hachulla, Eric [Auteur]
Hamidou, Mohamed [Auteur]
Kahn, Jean-Emmannuel [Auteur]
Legendre, Christophe [Auteur]
Le Quellec, Alain [Auteur]
Lhote, Francois [Auteur]
Lifermann, Francois [Auteur]
Mathian, Alexis [Auteur]
Neel, Antoine [Auteur]
Nunes, Hilario [Auteur]
Subra, Jean-Francois [Auteur]
Terrier, Benjamin [Auteur]
Mouthon, Luc [Auteur]
Diot, Elisabeth [Auteur]
Guillevin, Loic [Auteur]
Brillet, Pierre-Yves [Auteur]
Tcherakian, Colas [Auteur]

Journal title :

The Journal of rheumatology

Abbreviated title :

J. Rheumatol.

Publication date :

2019-12-01

ISSN :

0315-162X

English keyword(s) :

immunosuppressive agents
antineutrophil cytoplasmic antibody-associated vasculitis
age
bronchiectasis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To report on a large series of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and bronchiectasis, with a specific focus on the timeline of occurrence of both features. Retrospective ...
Show more >To report on a large series of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and bronchiectasis, with a specific focus on the timeline of occurrence of both features. Retrospective nationwide multicenter study of patients diagnosed with both AAV and bronchiectasis. Sixty-one patients were included, among whom 27 (44.25%) had microscopic polyangiitis (MPA), 27 (44.25%) had granulomatosis with polyangiitis (GPA), and 7 (11.5%) had eosinophilic GPA. Thirty-nine (64%) had myeloperoxidase (MPO)-ANCA and 13 (21%) had proteinase 3-ANCA. The diagnosis of bronchiectasis either preceded (n = 25; median time between both diagnoses: 16 yrs, IQR 4-54 yrs), was concomitant to (n = 12), or followed (n = 24; median time between both diagnoses: 1, IQR 0-6 yrs) that of AAV. Patients in whom bronchiectasis precedes the onset of AAV (B-AAV group) have more frequent mononeuritis multiplex, MPA, MPO-ANCA, and a 5-fold increase of death. The occurrence of an AAV relapse tended to be protective against bronchiectasis worsening (HR 0.6, 95% CI 0.4-0.99, PPP The association of bronchiectasis with AAV is likely not accidental and is mostly associated with MPO-ANCA. Patients in whom bronchiectasis precedes the onset of AAV tend to have distinct clinical and biological features and could carry a worse prognosis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:28:36Z