Title :

Prevalence of and factors associated with extraintestinal manifestations and their remission in inflammatory bowel disease: the EXTRA prospective study from the GETAID.

Author(s) :

Guillo, Lucas [Auteur]
Hôpital Nord [CHU - APHM]
Savoye, Guillaume [Auteur]
CHU Rouen
Amiot, Aurelien [Auteur]
Hôpital Henri Mondor
Gilletta, Cyrielle [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Nachury, Maria [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Dib, Nina [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Bourreille, Arnaud [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Roblin, Xavier [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Caillo, Ludovic [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Allez, Matthieu [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Picon, Laurence [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Hébuterne, Xavier [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Seksik, Philippe [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Chupin, Antoine [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Buisson, Anthony [Auteur]
CHU Clermont-Ferrand
Brixi, Hédia [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Altwegg, Romain [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Simon, Marion [Auteur]
Institut Mutualiste de Montsouris [IMM]
Amil, Morgane [Auteur]
Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon [CHD Vendée]
Laharie, David [Auteur]

Bouguen, Guillaume [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Serrero, Melanie [Auteur]
Hôpital Nord [CHU - APHM]
Elgharabawy, Yasmine [Auteur]
Groupe d’Étude Thérapeutique des Affections Inflammatoires du Tube Digestif [GETAID]
Peyrin-Biroulet, Laurent [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]

Journal title :

Clinical and translational gastroenterology

Abbreviated title :

Clin Transl Gastroenterol

Publication date :

2023-08-10

ISSN :

2155-384X

English abstract : [en]

Abstract Background and aims: Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors for EIMs. Study aimed to ...
Show more >Abstract Background and aims: Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors for EIMs. Study aimed to prospectively investigate the epidemiology, risk factors for EIM occurrence and EIM remission in a large IBD cohort. Methods: We conducted a cross-sectional study in 30 French referral centers. Between May to June 2021, all consecutive patients attending to hospital appointment were systematically invited to fill out a questionnaire. Results: A total of 1971 consecutive patients with IBD were analyzed. There were 1056 women (53.8%), and the median age of patients was 41 years [31; 54]. The median disease duration was 11 years [1; 18]. Overall, 544 (27.6%) had at least one EIM. In 20.2% of case, patient had multiple EIMs. The most frequent EIMs were rheumatological (19%) and dermatological (10%) manifestations. Immunosuppressant treatment (OR=2.56; p<0.001) was a risk factor for EIM, while the Montreal A3 classification (OR=0.61, p=0.023) and male gender (OR=0.61, p<0.001) were associated with a lower risk for EIM occurrence. IBD current clinical remission (OR=2.42; p<0.001) and smoking cessation (OR=2.98; p<0.001) were associated factors for EIM remission. Conversely, age at IBD diagnosis (OR=0.98; p<0.018) was associated with a lower risk of EIM remission. Conclusion: One quarter of patients had at least one EIM. Beyond factors associated with the presence of EIMs, patients with IBD current clinical remission and smoking cessation are more likely to achieve EIM remission, while increasing age at IBD diagnosis is associated with decreased chance of remission.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T22:07:07Z
2024-03-11T13:01:12Z