Title :

Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms: A Delphi-Based International Consensus.

Author(s) :

Brüggen, Marie-Charlotte [Auteur]
University hospital of Zurich [Zurich]
Universität Zürich [Zürich] = University of Zurich [UZH]
Walsh, Sarah [Auteur]
King's College Hospital [KCH]
Ameri, M. Milad [Auteur]
University hospital of Zurich [Zurich]
Universität Zürich [Zürich] = University of Zurich [UZH]
Anasiewicz, Natalie [Auteur]
University hospital of Zurich [Zurich]
Maverakis, Emanual [Auteur]
University of California [UC]
French, Lars E. [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
University of Miami Leonard M. Miller School of Medicine [UMMSM]
Ingen-Housz-Oro, Saskia [Auteur]
Epidemiology in Dermatology and Evaluation in Therapeutics [EpiDermE]
Hôpital Henri Mondor
Abe, R. [Auteur]
Ardern-Jones, M. [Auteur]
Assier, H. [Auteur]
Barbaud, A. [Auteur]
Bensaid, B. [Auteur]
Bernal, W. [Auteur]
Bernier, C. [Auteur]
Brassard, A. [Auteur]
Brezinová, E. [Auteur]
Cabañas, R. [Auteur]
Cardones, A. [Auteur]
Chu, C. Y. [Auteur]
Chua, S. L. [Auteur]
Descamps, V. [Auteur]
Didona, B. [Auteur]
Divito, S. J. [Auteur]
Dodiuk-Gad, R. [Auteur]
Elman, S. [Auteur]
Gaspar, K. [Auteur]
Mortz, C. G. [Auteur]
Hama, N. [Auteur]
Lee, H. Y. [Auteur]
Horváth, B. [Auteur]
Jörg, L. [Auteur]
Kaffenberger, B. H. [Auteur]
Kucinskiene, V. [Auteur]
Lebrun-Vignes, B. [Auteur]
Lehloenya, R. J. [Auteur]
Meyersburg, D. [Auteur]
Micheletti, R. [Auteur]
Milpied, B. [Auteur]
Miyagawa, F. [Auteur]
Mostaghimi, A. [Auteur]
Nägeli, M. [Auteur]
Naldi, L. [Auteur]
Oppel, E. [Auteur]
Phillips, E. J. [Auteur]
Pirani, T. [Auteur]
Ranki, A. [Auteur]
Mälkönen, T. [Auteur]
Rosenbach, M. [Auteur]
Salavastru, C. [Auteur]
staumont, delphine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sandberg, H. [Auteur]
Setterfield, J. [Auteur]
Shinkai, K. [Auteur]
Shiohara, T. [Auteur]
Soria, A. [Auteur]
Tartar, D. [Auteur]
Tiplica, G. S. [Auteur]
Traidl, S. [Auteur]
Vorobyev, A. [Auteur]
Von Wachter, C. [Auteur]
Worswick, S. [Auteur]
Cho, Y. T. [Auteur]

Journal title :

JAMA Dermatology

Abbreviated title :

JAMA Dermatol

Publication date :

2023-11-16

ISSN :

2168-6084

English abstract : [en]

Importance Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and ...
Show more >Importance Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment. Objective To reach an international, Delphi-based multinational expert consensus on the diagnostic workup, severity assessment, and treatment of patients with DRESS. Design, Setting, and Participants The Delphi method was used to assess 100 statements related to baseline workup, evaluation of severity, acute phase, and postacute management of DRESS. Fifty-seven international experts in DRESS were invited, and 54 participated in the survey, which took place from July to September 2022. Main Outcomes/Measures The degree of agreement was calculated with the RAND-UCLA Appropriateness Method. Consensus was defined as a statement with a median appropriateness value of 7 or higher (appropriate) and a disagreement index of lower than 1. Results In the first Delphi round, consensus was reached on 82 statements. Thirteen statements were revised and assessed in a second round. A consensus was reached for 93 statements overall. The experts agreed on a set of basic diagnostic workup procedures as well as severity- and organ-specific further investigations. They reached a consensus on severity assessment (mild, moderate, and severe) based on the extent of liver, kidney, and blood involvement and the damage of other organs. The panel agreed on the main lines of DRESS management according to these severity grades. General recommendations were generated on the postacute phase follow-up of patients with DRESS and the allergological workup. Conclusions and Relevance This Delphi exercise represents, to our knowledge, the first international expert consensus on diagnostic workup, severity assessment, and management of DRESS. This should support clinicians in the diagnosis and management of DRESS and constitute the basis for development of future guidelines.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-03T22:13:22Z
2024-03-13T09:02:39Z