Genetic polymorphisms influence on sports ...
Document type :
Communication dans un congrès avec actes
Permalink :
Title :
Genetic polymorphisms influence on sports injuries and muscle damage
Author(s) :
Delforge, Etienne [Auteur]
Boissiere, Julien [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Imbert, Sebastien [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Dine, Gerard [Auteur]
Daussin, Frédéric [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Delforge, Etienne [Auteur]
Boissiere, Julien [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Imbert, Sebastien [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Dine, Gerard [Auteur]
Daussin, Frédéric [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Delforge, Etienne [Auteur]
Conference title :
European College of Sport Science
City :
Paris
Start date of the conference :
2023-07-04
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The practice of sports or physical activity has been acknowledged to be beneficial for health. However, the physical practice may also induce injuries related to the sport. Indeed, when related to 1000 hours of practice, ...
Show more >The practice of sports or physical activity has been acknowledged to be beneficial for health. However, the physical practice may also induce injuries related to the sport. Indeed, when related to 1000 hours of practice, injury incidence in training is 3.7 in football and 3.0 in rugby union whereas it increases to 36.0 and 81.0 (respectively) during matches. Injuries negatively affect the players’ performance and health, and may have financial implications for the athletes and/or their clubs. Therefore, avoiding players’ injuries became a priority and strategies are developed to limit them. Training workloads focused trainers’ and researchers’ attention as their monitoring allows to maximize the training processes and performance, and limit the occurrence of injury. Internal and external outcomes are used to characterize the training and competition load. For the same external workload, the internal responses differ for each people leading to different levels of fatigue or exercise-induced muscle damage. While a high training load and a certain amount of muscle damage are necessary to induce adaptations and performance increase, excessive muscle damage favor injury occurrence. Great inter-individual variations have been observed following a same external training load. Scientific evidence support that several factors are involved in the occurrence of injury or exercise-induced muscle damage. Besides exercise characteristics, individual risk factors, such as genetics, seem to be a component to take into account in injury mechanisms. Particularly, single genetic polymorphism, an alteration in DNA sequence, may alter the protein structure and its function within the cell. Studies support that genetic polymorphisms may be considered as a predisposing factor. In this context, identifying injury-predisposing polymorphisms is of interest to improve training load prescription. METHODS: A review was achieved to identify genetic polymorphisms which increase injuries and muscle damage susceptibility. RESULTS: Several genetic polymorphisms have been identified during the last decade involving muscles, ligaments, or tendons-related genes. These genetic polymorphisms can impact, positively or negatively the risk, the incidence, and the severity of injuries. Among them, the major genes identified were ACE, ACTN3, COL5A1, IL6, MCT1, MMP3, and HGF. CONCLUSION: The present study supports the interest to assess genetic polymorphisms in athletes to better individualize training strategies.Show less >
Show more >The practice of sports or physical activity has been acknowledged to be beneficial for health. However, the physical practice may also induce injuries related to the sport. Indeed, when related to 1000 hours of practice, injury incidence in training is 3.7 in football and 3.0 in rugby union whereas it increases to 36.0 and 81.0 (respectively) during matches. Injuries negatively affect the players’ performance and health, and may have financial implications for the athletes and/or their clubs. Therefore, avoiding players’ injuries became a priority and strategies are developed to limit them. Training workloads focused trainers’ and researchers’ attention as their monitoring allows to maximize the training processes and performance, and limit the occurrence of injury. Internal and external outcomes are used to characterize the training and competition load. For the same external workload, the internal responses differ for each people leading to different levels of fatigue or exercise-induced muscle damage. While a high training load and a certain amount of muscle damage are necessary to induce adaptations and performance increase, excessive muscle damage favor injury occurrence. Great inter-individual variations have been observed following a same external training load. Scientific evidence support that several factors are involved in the occurrence of injury or exercise-induced muscle damage. Besides exercise characteristics, individual risk factors, such as genetics, seem to be a component to take into account in injury mechanisms. Particularly, single genetic polymorphism, an alteration in DNA sequence, may alter the protein structure and its function within the cell. Studies support that genetic polymorphisms may be considered as a predisposing factor. In this context, identifying injury-predisposing polymorphisms is of interest to improve training load prescription. METHODS: A review was achieved to identify genetic polymorphisms which increase injuries and muscle damage susceptibility. RESULTS: Several genetic polymorphisms have been identified during the last decade involving muscles, ligaments, or tendons-related genes. These genetic polymorphisms can impact, positively or negatively the risk, the incidence, and the severity of injuries. Among them, the major genes identified were ACE, ACTN3, COL5A1, IL6, MCT1, MMP3, and HGF. CONCLUSION: The present study supports the interest to assess genetic polymorphisms in athletes to better individualize training strategies.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Univ. Artois
Univ. Littoral Côte d’Opale
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2024-02-05T09:43:16Z
2024-02-07T09:03:33Z
2024-02-07T09:03:33Z
Files
- Poster Delforge ECSS 2023 version finale.pdf
- Version finale acceptée pour publication (postprint)
- Open access
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