Title :

The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party.

Author(s) :

Gjærde, Lars Klingen [Auteur]
Copenhagen University Hospital
Ruutu, Tapani [Auteur]
Helsinki University Hospital [Finland] [HUS]
Peczynski, Christophe [Auteur]
Boreland, William [Auteur]
Kröger, Nicolaus [Auteur]
Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] [UKE]
Blaise, Didier [Auteur]
Institut Paoli-Calmettes [IPC]
Schroeder, Thomas [Auteur]
University Children's Hospital of Essen
Peffault De Latour, Régis [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Gedde-Dahl, Tobias [Auteur]
Oslo University Hospital [Oslo]
Kulagin, Aleksandr [Auteur]
Pavlov First Saint Petersburg State Medical University [St. Petersburg]
Sengeløv, Henrik [Auteur]
Rigshospitalet [Copenhagen]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Finke, Jürgen [Auteur]

Eder, Matthias [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Basak, Grzegorz W. [Auteur]
Medical University of Warsaw - Poland
Moiseev, Ivan [Auteur]
Pavlov First Saint Petersburg State Medical University [St. Petersburg]
Schoemans, Hélène [Auteur]
University Hospitals Leuven [Leuven]
Koenecke, Christian [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Penack, Olaf [Auteur]
Charité - UniversitätsMedizin = Berlin University Medicine
Peric, Zinaida [Auteur]
University Hospital Centre Zagreb

Journal title :

Bone Marrow Transplantation

Abbreviated title :

Bone Marrow Transplant

Publication date :

2023-12-09

ISSN :

1476-5365

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Obesity and diabetes can modulate immune responses, which may impact allogeneic HCT outcomes and GvHD. From the EBMT registry, we included 36,539 adult patients who underwent allogeneic HCT for a hematological malignancy ...
Show more >Obesity and diabetes can modulate immune responses, which may impact allogeneic HCT outcomes and GvHD. From the EBMT registry, we included 36,539 adult patients who underwent allogeneic HCT for a hematological malignancy between 2016 and 2020. Of these, 5228 (14%) had obesity (BMI ≥ 30 kg/m2), 1415 (4%) had diabetes (requiring treatment with insulin or oral hypoglycemics), and 688 (2%) had obesity + diabetes pre-transplantation. Compared with patients without diabetes or obesity, the hazard ratio (HR) of grade II–IV acute GvHD was 1.00 (95% confidence interval [CI] 0.94–1.06, p = 0.89) for patients with obesity, 0.95 (CI 0.85–1.07, p = 0.43) for patients with diabetes, and 0.96 (CI 0.82–1.13, p = 0.63) for patients with obesity + diabetes. Non-relapse mortality was higher in patients with obesity (HR 1.08, CI 1.00–1.17, p = 0.047), diabetes (HR 1.40, CI 1.24–1.57, p < 0.001), and obesity + diabetes (HR 1.38, CI 1.16–1.64, p < 0.001). Overall survival after grade II–IV acute GvHD was lower in patients with diabetes (HR 1.46, CI 1.25–1.70, p < 0.001). Pre-transplantation diabetes and obesity did not influence the risk of developing acute GvHD, but pre-transplantation diabetes was associated with poorer survival after acute GvHD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-06T22:15:57Z
2024-03-21T13:35:51Z