Title :

Impact of Risk Factors on COVID-19 Outcomes in Unvaccinated People with Rheumatic Diseases.

Author(s) :

Yazdany, Jinoos [Auteur]
University of California [UC]
Ware, Anna [Auteur]
Veterans Affairs Palo Alto Healthcare System
Wallace, Zachary S. [Auteur]
Massachusetts General Hospital [Boston]
Harvard Medical School [Boston] [HMS]
Bhana, Suleman [Auteur]
Pfizer
Grainger, Rebecca [Auteur]
University of Otago [Dunedin, Nouvelle-Zélande]
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Richez, Christophe [Auteur]
CHU Bordeaux
Cacoub, Patrice [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Hausmann, Jonathan S. [Auteur]
Harvard Medical School [Boston] [HMS]
Liew, Jean W. [Auteur]
Boston University School of Medicine [BUSM]
Sirotich, Emily [Auteur]
Yale School of Medicine [New Haven, Connecticut] [YSM]
Jacobsohn, Lindsay [Auteur]
University of California [UC]
Strangfeld, Anja [Auteur]
Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
Mateus, Elsa F. [Auteur]
Hyrich, Kimme L. [Auteur]
Manchester Academic Health Science Centre [MAHSC]
Gossec, Laure [Auteur]
Carmona, L. [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Lawson-Tovey, Saskia [Auteur]
Manchester Academic Health Science Centre [MAHSC]
Kearsley-Fleet, Lianne [Auteur]
University of Manchester [Manchester]
Schaefer, Martin [Auteur]
Ribeiro, Sandra Lucia Euzebio [Auteur]
Federal University of Amazonas
Al-Emadi, Samar [Auteur]
Hasseli, Rebecca [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Müller-Ladner, Ulf [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Specker, Christof [Auteur]
Kliniken Essen-Mitte
Schulze-Koops, Hendrik [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Bernardes, Miguel [Auteur]
Universidade do Porto = University of Porto
Machado Fraga, Vanessa [Auteur]
Hospital Garcia de Orta [EPE]
Rodrigues, Ana Maria [Auteur]
Universidade Nova de Lisboa = NOVA University Lisbon [NOVA]
Sparks, Jeffrey A. [Auteur]
Brigham and Women's Hospital [Boston]
Ljung, Lotta [Auteur]
Karolinska Institutet [Stockholm]
Di Giuseppe, Daniela [Auteur]
Karolinska Institutet [Stockholm]
Tidblad, Liselotte [Auteur]
Karolinska Institutet [Stockholm]
Wise, Leanna [Auteur]
University of Southern California [USC]
Duarte-García, Alí [Auteur]
Mayo Clinic [Rochester]
Ugarte-Gil, Manuel F. [Auteur]
Colunga-Pedraza, Iris Jazmín [Auteur]
Martínez-Martínez, Marco Ulises [Auteur]
Universidad Autonoma de San Luis Potosi [México] [UASLP]
Alpizar-Rodriguez, Deshire [Auteur]
Xavier, Ricardo Machado [Auteur]
Universidade Federal do Rio Grande do Sul [Porto Alegre] [UFRGS]
Isnardi, Carolina A. [Auteur]
Pera, Mariana [Auteur]
Hospital del Niño Jesus, San Miguel de Tucumán
Pons-Estel, Guillermo [Auteur]
Universidad Nacional de Rosario [Santa Fe]
Izadi, Zara [Auteur]
University of California [UC]
Gianfrancesco, Milena A. [Auteur]
University of California [UC]
Carrara, Greta [Auteur]
Scirè, Carlo Alberto [Auteur]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca [UNIMIB]
Zanetti, Anna [Auteur]
Machado, Pedro M. [Auteur]
University College London Hospitals NHS Foundation Trust [London, UK] [UCLH]

Journal title :

Arthritis Care & Research = Arthritis Care and Research

Abbreviated title :

Arthritis Care Res (Hoboken)

Publication date :

2023-08-31

ISSN :

2151-4658

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective Approximately one third of individuals worldwide have not received a COVID‐19 vaccine. Although studies have investigated risk factors linked to severe COVID‐19 among unvaccinated people with rheumatic diseases ...
Show more >Objective Approximately one third of individuals worldwide have not received a COVID‐19 vaccine. Although studies have investigated risk factors linked to severe COVID‐19 among unvaccinated people with rheumatic diseases (RDs), we know less about whether these factors changed as the pandemic progressed. We aimed to identify risk factors associated with severe COVID‐19 in unvaccinated individuals in different pandemic epochs corresponding to major variants of concern. Methods Patients with RDs and COVID‐19 were entered into the COVID‐19 Global Rheumatology Alliance Registry between March 2020 and June 2022. An ordinal logistic regression model (not hospitalized, hospitalized, and death) was used with date of COVID‐19 diagnosis, age, sex, race and/or ethnicity, comorbidities, RD activity, medications, and the human development index (HDI) as covariates. The main analysis included all unvaccinated patients across COVID‐19 pandemic epochs; subanalyses stratified patients according to RD types. Results Among 19,256 unvaccinated people with RDs and COVID‐19, those who were older, male, had more comorbidities, used glucocorticoids, had higher disease activity, or lived in lower HDI regions had worse outcomes across epochs. For those with rheumatoid arthritis, sulfasalazine and B‐cell–depleting therapy were associated with worse outcomes, and tumor necrosis factor inhibitors were associated with improved outcomes. In those with connective tissue disease or vasculitis, B‐cell–depleting therapy was associated with worse outcomes. Conclusion Risk factors for severe COVID‐19 outcomes were similar throughout pandemic epochs in unvaccinated people with RDs. Ongoing efforts, including vaccination, are needed to reduce COVID‐19 severity in this population, particularly in those with medical and social vulnerabilities identified in this study.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-06T22:29:16Z
2024-03-21T14:19:24Z