Title :

Characterization of Two Parabacteroides distasonis Candidate Strains as New Live Biotherapeutics against Obesity

Author(s) :

Cuffaro, Bernardo [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Boutillier, Denise [Auteur]
Institut Pasteur de Lille
Desramaut, Jérémy [Auteur]
Institut Pasteur de Lille
Jablaoui, Amin [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Werkmeister, Elisabeth [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Université de Lille
Trottein, Francois [Auteur]
Institut Pasteur de Lille
Centre National de la Recherche Scientifique [CNRS]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Waligora-Dupriet, Anne-Judith [Auteur]
Université Paris Cité [UPCité]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Rhimi, Moez [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Maguin, Emmanuelle [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Grangette, Corinne [Auteur]
Institut Pasteur de Lille
Centre National de la Recherche Scientifique [CNRS]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Cells

Pages :

pp 1260

Publisher :

MDPI

Publication date :

2023

ISSN :

2073-4409

English keyword(s) :

Parabacteroides
holobiont
live biotherapeutic products
microbiota
obesity
probiotics

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The gut microbiota is now considered as a key player in the development of metabolic dysfunction. Therefore, targeting gut microbiota dysbiosis has emerged as a new therapeutic strategy, notably through the use of live gut ...
Show more >The gut microbiota is now considered as a key player in the development of metabolic dysfunction. Therefore, targeting gut microbiota dysbiosis has emerged as a new therapeutic strategy, notably through the use of live gut microbiota-derived biotherapeutics. We previously highlighted the anti-inflammatory abilities of two Parabacteroides distasonis strains. We herein evaluate their potential anti-obesity abilities and show that the two strains induced the secretion of the incretin glucagon-like peptide 1 in vitro and limited weight gain and adiposity in obese mice. These beneficial effects are associated with reduced inflammation in adipose tissue and the improvement of lipid and bile acid metabolism markers. P. distasonis supplementation also modified the Actinomycetota, Bacillota and Bacteroidota taxa of the mice gut microbiota. These results provide better insight into the capacity of P. distasonis to positively influence host metabolism and to be used as novel source of live biotherapeutics in the treatment and prevention of metabolic-related diseases.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL