Title :

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis

Author(s) :

Lecoutre, Simon [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Montel, Valerie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Environnement périnatal et croissance - EA 4489 [EPS]
Vallez, Emmanuelle [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut Pasteur de Lille
Pourpe, Charlene [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Delmont, Anne [Auteur]
Eury, Elodie [Auteur]
Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 [EGENODIA (GI3M)]
Verbanck, Marie [Auteur]
Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 [EGENODIA (GI3M)]
Dickes-Coopman, Anne [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Daubersies, Pierre [Auteur]
Lesage, Jean [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Laborie, Christine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Tailleux, Anne [Auteur]
Institut Pasteur de Lille
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Breton, Christophe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Vieau, didier [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]

Journal title :

AJP - Endocrinology and Metabolism
American journal of physiology. Endocrinology and metabolism

Publisher :

American Physiological Society

Publication date :

2019-10-22

ISSN :

0193-1849

English keyword(s) :

maternal undemutrition
gene expression
microarray
programming
high-fat diet

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Clinical and animal studies have reported an association between low birth weight and the development of nonalcoholic fatty liver disease (NAFLD) in offspring. Using a model of prenatal maternal 70% food restriction diet ...
Show more >Clinical and animal studies have reported an association between low birth weight and the development of nonalcoholic fatty liver disease (NAFLD) in offspring. Using a model of prenatal maternal 70% food restriction diet (FR30) in the rat, we previously showed that maternal undernutrition predisposes offspring to altered lipid metabolism in adipose tissue, especially on a high-fat (HF) diet. Here, using microarray-based expression profiling combined with metabolic, endocrine, biochemical, histological, and lipidomic approaches, we assessed whether FR30 procedure sensitizes adult male offspring to impaired lipid metabolism in the liver. No obvious differences were noted in the concentrations of triglycerides, cholesterol, and bile acids in the liver of 4-mo-old FR30 rats whichever postweaning diet was used. However, several clues suggest that offspring's lipid metabolism and steatosis are modified by maternal undernutrition. First, lipid composition was changed (i.e., higher total saturated fatty acids and lower elaidic acid) in the liver, whereas larger triglyceride droplets were observed in hepatocytes of undernourished rats. Second, FR30 offspring exhibited long-Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL