Title :

Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel.

Author(s) :

Lefol, Lise-Anne [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Bawuah, Prince [Auteur]
University of Cambridge [UK] [CAM]
Zeitler, J. Axel [Auteur]
University of Cambridge [UK] [CAM]
Verin, Jérémy [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Danede, Florence [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Willart, Jean-François [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

International Journal of Pharmaceutics: X

Abbreviated title :

Int J Pharm X

Volume number :

6

Pages :

100220

Publication date :

2024-01-01

ISSN :

2590-1567

English keyword(s) :

PLGA
Microparticles
Drug release mechanism
Experimental setup
Swelling
Agarose gel

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles ...
Show more >This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug loading was about 48%. The surface of the microparticles appeared initially smooth and non-porous. In contrast, the internal microstructure of the particles exhibited a continuous network of tiny pores. Ibuprofen release from single microparticles was measured into agarose gels and well-agitated phosphate buffer pH 7.4. Optical microscopy, scanning electron microscopy, differential scanning calorimetry, X-ray powder diffraction, and X-ray μCT imaging were used to characterize the microparticles before and after exposure to the release media. Importantly, ibuprofen release was much slower in the presence of a surrounding agarose gel, e.g., the complete release took two weeks vs. a few days in well agitated phosphate buffer. This can probably be attributed to the fact that the hydrogel sterically hinders substantial system swelling and, thus, slows down the related increase in drug mobility. In addition, in this particular case, the convective flow in agitated bulk fluid likely damages the thin PLGA layer at the microparticles' surface, giving the outer aqueous phase more rapid access to the inner continuous pore network: Upon contact with water, the drug dissolves and rapidly diffuses out through a continuous network of water-filled channels. Without direct surface access, most of the drug “has to wait” for the onset of substantial system swelling to be released.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Submission date :

2024-02-09T22:01:27Z
2024-02-26T08:19:07Z
2024-04-02T13:10:51Z