Release of liposomes from hyaluronic ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
Release of liposomes from hyaluronic acid-based hybrid systems: Effects of liposome surface and size
Auteur(s) :
Jaudoin, Céline [Auteur]
Institut Galien Paris-Saclay [IGPS]
Gehrke, Maria Maue [Auteur]
Institut Galien Paris-Saclay [IGPS]
Grillo, Isabelle [Auteur]
Institut Laue-Langevin [ILL]
Cousin, Fabrice [Auteur]
Laboratoire Léon Brillouin [LLB - UMR 12]
Ouldali, Malika [Auteur]
Institut de Biologie Intégrative de la Cellule [I2BC]
Arteni, Ana-Andreea [Auteur]
Institut de Biologie Intégrative de la Cellule [I2BC]
Ferrary, Evelyne [Auteur]
Institut de l'Audition [Paris] [IDA]
CHU Pitié-Salpêtrière [AP-HP]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Simelière, Fanny [Auteur]
Institut Galien Paris-Saclay [IGPS]
Bochot, Amélie [Auteur]
Institut Galien Paris-Saclay [IGPS]
Agnely, Florence [Auteur]
Institut Galien Paris-Saclay [IGPS]
Institut Galien Paris-Saclay [IGPS]
Gehrke, Maria Maue [Auteur]
Institut Galien Paris-Saclay [IGPS]
Grillo, Isabelle [Auteur]
Institut Laue-Langevin [ILL]
Cousin, Fabrice [Auteur]
Laboratoire Léon Brillouin [LLB - UMR 12]
Ouldali, Malika [Auteur]
Institut de Biologie Intégrative de la Cellule [I2BC]
Arteni, Ana-Andreea [Auteur]
Institut de Biologie Intégrative de la Cellule [I2BC]
Ferrary, Evelyne [Auteur]
Institut de l'Audition [Paris] [IDA]
CHU Pitié-Salpêtrière [AP-HP]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Simelière, Fanny [Auteur]
Institut Galien Paris-Saclay [IGPS]
Bochot, Amélie [Auteur]
Institut Galien Paris-Saclay [IGPS]
Agnely, Florence [Auteur]
Institut Galien Paris-Saclay [IGPS]
Titre de la revue :
International Journal of Pharmaceutics
Nom court de la revue :
Int. J. Pharm.
Numéro :
648
Pagination :
123560
Date de publication :
2024-01-01
ISSN :
0378-5173
Mot(s)-clé(s) en anglais :
Cryogenic electron microscopy
Erosion
Microstructure
Migration
Small angle neutron scattering
Swelling
Erosion
Microstructure
Migration
Small angle neutron scattering
Swelling
Discipline(s) HAL :
Chimie
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Mixtures of hyaluronic acid (HA, in the semi-dilute entangled regime) with liposomes (high lipid concentration) exhibit a great interest in drug delivery. Considering the difference of microstructures when varying the ...
Lire la suite >Mixtures of hyaluronic acid (HA, in the semi-dilute entangled regime) with liposomes (high lipid concentration) exhibit a great interest in drug delivery. Considering the difference of microstructures when varying the liposome surface, we aimed to determine if liposome characteristics (surface and size) also influenced their release from these hybrid systems and to explore the mechanisms involved. Small-angle neutron scattering, cryogenic electron microscopy, zetametry, and dynamic light scattering were used to characterize liposomes. The implemented Transwell® model (two compartments separated by a polycarbonate membrane) showed that both size and surface governed liposome release. At 150 nm, anionic liposomes with or without poly(ethylene glycol) chains (PEG) migrated from HA-liposome mixtures, while cationic and neutral ones did not. Furthermore, increasing the size of PEGylated liposomes up to 200 nm or more strongly hindered their migration. Below 200 nm, the smaller the liposome size, the faster the release. Multiple and complex mechanisms (interactions between HA and liposomes, water exchanges, liposome migration, swelling and erosion, and HA reptation) were involved. Their relative importance depended on liposome characteristics. The Transwell® model is a pertinent tool to assess in vitro the release of liposomes over several weeks and discriminate the formulations, depending on the foreseen therapeutic strategy.Lire moins >
Lire la suite >Mixtures of hyaluronic acid (HA, in the semi-dilute entangled regime) with liposomes (high lipid concentration) exhibit a great interest in drug delivery. Considering the difference of microstructures when varying the liposome surface, we aimed to determine if liposome characteristics (surface and size) also influenced their release from these hybrid systems and to explore the mechanisms involved. Small-angle neutron scattering, cryogenic electron microscopy, zetametry, and dynamic light scattering were used to characterize liposomes. The implemented Transwell® model (two compartments separated by a polycarbonate membrane) showed that both size and surface governed liposome release. At 150 nm, anionic liposomes with or without poly(ethylene glycol) chains (PEG) migrated from HA-liposome mixtures, while cationic and neutral ones did not. Furthermore, increasing the size of PEGylated liposomes up to 200 nm or more strongly hindered their migration. Below 200 nm, the smaller the liposome size, the faster the release. Multiple and complex mechanisms (interactions between HA and liposomes, water exchanges, liposome migration, swelling and erosion, and HA reptation) were involved. Their relative importance depended on liposome characteristics. The Transwell® model is a pertinent tool to assess in vitro the release of liposomes over several weeks and discriminate the formulations, depending on the foreseen therapeutic strategy.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2024-02-09T22:09:48Z
2024-02-23T14:40:12Z
2024-02-23T14:40:12Z