Title :

Does KONO-S anastomosis reduce recurrence in Crohn's disease compared to conventional ileocolonic anastomosis? A nationwide propensity score-matched study from GETAID Chirurgie Group (KoCoRICCO study).

Author(s) :

Alibert, Line [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Betton, Louis [Auteur]
CHU Saint-Antoine [AP-HP]
Falcoz, Antoine [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Manceau, Gilles [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Benoist, Stéphane [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Zerbib, Philippe [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Podevin, Juliette [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Maggiori, Léon [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Brouquet, Antoine [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Tyrode, Gaëlle [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Vuitton, Lucine [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Vernerey, Dewi [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Lefevre, Jérémie H. [Auteur]
CHU Saint-Antoine [AP-HP]
Lakkis, Zaher [Auteur]

Journal title :

Journal of Crohn's and Colitis

Abbreviated title :

J Crohns Colitis

Publication date :

2023-10-18

ISSN :

1876-4479

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and Aims Postoperative recurrence is a major concern in Crohn’s disease. The Kono-S anastomosis has been described to reduce the rate of recurrence. However, the level of evidence for its effectiveness remains ...
Show more >Background and Aims Postoperative recurrence is a major concern in Crohn’s disease. The Kono-S anastomosis has been described to reduce the rate of recurrence. However, the level of evidence for its effectiveness remains low. The KoCoRICCO study aimed to compare outcomes between Kono-S anastomosis and conventional anastomosis in two nationwide, prospective cohorts. Methods Adult patients with Crohn’s disease, who underwent ileocolonic resection with Kono-S anastomosis, were prospectively included in seven referral centres between 2020 and 2022. Patients with conventional side-to-side anastomosis were enrolled from a previously published cohort. A propensity score analysis was performed to compare recurrence at first endoscopy in a matched 1:2 ratio population. Results A total of 433 patients with ileocolonic anastomosis were enrolled, of whom 155 had a Kono-S anastomosis. Before matching, both groups were unbalanced for preoperative, intraoperative, and postoperative characteristics. After matching patients with available endoscopic follow-up, endoscopic recurrence ≥i2 was found in 47.5% of the Kono-S group and 44.3% of the conventional side-to-side group [p = 0.6745]. Conclusions The KoCoRICCO study suggests that Kono-S anastomosis does not reduce the risk of endoscopic recurrence in Crohn’s disease compared with conventional side-to-side anastomosis. Further research with a longer follow-up is necessary to determine whether there is a potential benefit on surgical recurrence.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-09T22:19:19Z
2024-03-22T10:04:55Z