Titre :

Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma.

Auteur(s) :

Bassot, Arthur [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Dragic, Helena [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Haddad, Sarah Al [Auteur]
Geneva University Hospitals and Geneva University
Moindrot, Laurine [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Geneva University Hospitals and Geneva University
Odouard, Soline [Auteur]
Geneva University Hospitals and Geneva University
Corlazzoli, Francesca [Auteur]
Geneva University Hospitals and Geneva University
Marinari, Eliana [Auteur]
Geneva University Hospitals and Geneva University
Bomane, Alexandra [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Brassens, Augustin [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Marteyn, Antoine [Auteur]
Geneva University Hospitals and Geneva University
Hibaoui, Youssef [Auteur]
Fribourg Cantonal Hospital
Petty, Tom J. [Auteur]
Swiss Institute of Bioinformatics [Genève] [SIB]
Chalabi-Dchar, Mounira [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Larrouquere, Louis [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Zdobnov, Evgeny M. [Auteur]
Swiss Institute of Bioinformatics [Genève] [SIB]
Legrand, Noemie [Auteur]
Geneva University Hospitals and Geneva University
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Tamburini, Jérôme [Auteur]
Geneva University Hospitals and Geneva University
Lincet, Hubert [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Castets, Marie [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Yebra, Mayra [Auteur]
Moores Cancer Center [La Jolla]
Migliorini, Denis [Auteur]
Geneva University Hospitals and Geneva University
Dutoit, Valérie [Auteur]
Geneva University Hospitals and Geneva University
Walker, Paul R. [Auteur]
Geneva University Hospitals and Geneva University
Preynat-Seauve, Olivier [Auteur]
Geneva University Hospitals and Geneva University
Dietrich, Pierre-Yves [Auteur]
Geneva University Hospitals and Geneva University
Cosset, Érika [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Geneva University Hospitals and Geneva University

Titre de la revue :

Cell Death and Disease

Nom court de la revue :

Cell Death Dis

Numéro :

14

Pagination :

630

Date de publication :

2023-10-04

ISSN :

2041-4889

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts, microRNAs (miRNAs) are key molecules in the control of biological processes ...
Lire la suite >Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts, microRNAs (miRNAs) are key molecules in the control of biological processes and are thereby promising therapeutic targets for GBM patients. In this regard, we recently reported miRNAs as strong modulators of GBM aggressiveness. Here, using an integrative and comprehensive analysis of the TCGA database and the transcriptome of GBM biopsies, we identified three critical and clinically relevant miRNAs for GBM, miR-17-3p, miR-222, and miR-340. In addition, we showed that the combinatorial modulation of three of these miRNAs efficiently inhibited several biological processes in patient-derived GBM cells of all these three GBM subtypes (Mesenchymal, Proneural, Classical), induced cell death, and delayed tumor growth in a mouse tumor model. Finally, in a doxycycline-inducible model, we observed a significant inhibition of GBM stem cell viability and a significant delay of orthotopic tumor growth. Collectively, our results reveal, for the first time, the potential of miR-17-3p, miR-222 and miR-340 multi-targeting as a promising therapeutic strategy for GBM patients.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Date de dépôt :

2024-02-09T22:20:19Z
2024-03-22T10:38:56Z