Increasing morbidity and mortality of ...
Document type :
Article dans une revue scientifique
DOI :
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Title :
Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital
Author(s) :
Battistolo, Julien [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Glampedakis, Emmanouil [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Damonti, Lauro [Auteur]
Bern University Hospital [Berne] [Inselspital]
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Grandbastien, Bruno [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Kalbermatter, Laetitia [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Pagani, Jean‐Luc [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Eggimann, Philippe [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Bochud, Pierre‐Yves [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Calandra, Thierry [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Marchetti, Oscar [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Lamoth, Frederic [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Université de Lausanne = University of Lausanne [UNIL]
Glampedakis, Emmanouil [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Damonti, Lauro [Auteur]
Bern University Hospital [Berne] [Inselspital]
Poissy, Julien [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Grandbastien, Bruno [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Kalbermatter, Laetitia [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Pagani, Jean‐Luc [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Eggimann, Philippe [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Bochud, Pierre‐Yves [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Calandra, Thierry [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Marchetti, Oscar [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Lamoth, Frederic [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Journal title :
Mycoses
Abbreviated title :
Mycoses
Volume number :
64
Pages :
1512-1520
Publisher :
Wiley
Publication date :
2021-10-19
ISSN :
0933-7407
English keyword(s) :
antifungal resistance
blood cultures
Candida
elderly
incidence
intensive care unit
invasive candidiasis
septic shock
blood cultures
Candida
elderly
incidence
intensive care unit
invasive candidiasis
septic shock
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
AbstractBackgroundThe epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non‐albicans Candida species and acquisition of antifungal resistance. In addition to ...
Show more >AbstractBackgroundThe epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non‐albicans Candida species and acquisition of antifungal resistance. In addition to microbiological surveys, epidemiological studies including clinical data are needed to assess the impact of candidemia on morbidity and mortality.ObjectivesTo assess the clinical and microbiological trends of candidemia in a Swiss university hospital.Patients/Methods.This single‐centre retrospective study compared the incidence of candidemia, Candida species distribution, antifungal resistance profiles, clinical characteristics and outcomes between two periods separated by one decade.ResultsA total of 170 candidemic episodes were included (68 from period 1, 2004‐2006, and 102 from period 2, 2014‐2017). Incidence of candidemia (0.85 to 0.97 episode/10,000 patient‐days), species distribution (55%–57% C albicans) and antifungal susceptibilities remained unchanged. During period 2, candidemia was more frequently observed in intensive care units (ICU, 38% vs 19% in period 1, P = .01) and amongst older patients (median age 68 vs 59 years old, P < .01) with more immunosuppressive conditions (24% vs 9%, P = .01). Candidemia in period 2 was more frequently followed by septic shock (23% vs 7% in period 1, P = .01) and ICU admission (42% vs 12%, P < .01) and was associated with higher mortality (34% vs 18%, P = .03). Overall, factors associated with mortality in multivariate analyses included cirrhosis, solid malignancies and ICU stay at the time of candidemia.ConclusionsDespite stable incidence, species distribution and antifungal resistance of candidemia, an epidemiological shift of the disease towards older and more critically ill patients was observed, with higher mortality rates.Show less >
Show more >AbstractBackgroundThe epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non‐albicans Candida species and acquisition of antifungal resistance. In addition to microbiological surveys, epidemiological studies including clinical data are needed to assess the impact of candidemia on morbidity and mortality.ObjectivesTo assess the clinical and microbiological trends of candidemia in a Swiss university hospital.Patients/Methods.This single‐centre retrospective study compared the incidence of candidemia, Candida species distribution, antifungal resistance profiles, clinical characteristics and outcomes between two periods separated by one decade.ResultsA total of 170 candidemic episodes were included (68 from period 1, 2004‐2006, and 102 from period 2, 2014‐2017). Incidence of candidemia (0.85 to 0.97 episode/10,000 patient‐days), species distribution (55%–57% C albicans) and antifungal susceptibilities remained unchanged. During period 2, candidemia was more frequently observed in intensive care units (ICU, 38% vs 19% in period 1, P = .01) and amongst older patients (median age 68 vs 59 years old, P < .01) with more immunosuppressive conditions (24% vs 9%, P = .01). Candidemia in period 2 was more frequently followed by septic shock (23% vs 7% in period 1, P = .01) and ICU admission (42% vs 12%, P < .01) and was associated with higher mortality (34% vs 18%, P = .03). Overall, factors associated with mortality in multivariate analyses included cirrhosis, solid malignancies and ICU stay at the time of candidemia.ConclusionsDespite stable incidence, species distribution and antifungal resistance of candidemia, an epidemiological shift of the disease towards older and more critically ill patients was observed, with higher mortality rates.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Glycobiology in fungal Pathogenesis and Clinical Applications
Submission date :
2024-02-16T10:20:11Z
2024-02-21T09:39:12Z
2024-02-21T09:39:12Z
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