Clinico-biological features and clonal hematopoiesis in patients with severe covid-19

Duployez, Nicolas; Demonchy, Jordane; Berthon, Celine; GOUTAY, Julien; Caplan, Morgan; Moreau, Anne-Sophie; Bignon, Anne; Marceau-Renaut, Alice; Garrigue, Delphine; Raczkiewicz, Imelda; Geffroy, Sandrine; Bucci, Maxime; Alidjinou, Kazali; Demaret, Julie; Labalette, Myriam; Brousseau, Thierry; Dupont, Annabelle; Rauch, Antoine; Poissy, Julien; Susen, Sophie; Preudhomme, Claude; Quesnel, Bruno

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.3390/cancers12071992

PMID :

32708264

Permalink :

http://hdl.handle.net/20.500.12210/107984

Title :

Clinico-biological features and clonal hematopoiesis in patients with severe covid-19

Author(s) :

Duployez, Nicolas [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Demonchy, Jordane [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Berthon, Celine [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
GOUTAY, Julien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Caplan, Morgan [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Moreau, Anne-Sophie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bignon, Anne [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Marceau-Renaut, Alice [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Garrigue, Delphine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Raczkiewicz, Imelda [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Geffroy, Sandrine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bucci, Maxime [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Alidjinou, Kazali [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Demaret, Julie [Auteur]

Institut d'Immunologie [CHRU Lille]
Labalette, Myriam [Auteur]

Institut d'Immunologie [CHRU Lille]
Brousseau, Thierry [Auteur]

Institut de Microbiologie [CHRU Lille]
Dupont, Annabelle [Auteur]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Rauch, Antoine [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Susen, Sophie [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Preudhomme, Claude [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Quesnel, Bruno [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Journal title :

Cancers

Pages :

1992

Publisher :

MDPI

Publication date :

2020-07-21

ISSN :

2072-6694

Keyword(s) :

COVID-19
clonal hematopoiesis
CHIP
sequencing
DNMT3A
TET2
SARS-CoV-2

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis ...
Show more >Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60-70 years, 70-80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings.Show less >

Language :

Anglais

Popular science :

Non

ANR Project :

ULNE

Collections :