Nonsense-Mediated mRNA Decay, a Finely ...
Document type :
Compte-rendu et recension critique d'ouvrage
Permalink :
Title :
Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism
Author(s) :
Lejeune, Fabrice [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Institut Pasteur de Lille
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Institut Pasteur de Lille
Journal title :
biomedicines
Pages :
141
Publisher :
MDPI
Publication date :
2022
ISSN :
2227-9059
English keyword(s) :
Nonsense-Mediated mRNA Decay
UPF proteins
regulation
gene expression
therapeutic perspectives
UPF proteins
regulation
gene expression
therapeutic perspectives
HAL domain(s) :
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
English abstract : [en]
Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in ...
Show more >Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.Show less >
Show more >Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.Show less >
Language :
Anglais
Popular science :
Non
Source :
Submission date :
2024-02-17T03:50:07Z
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