Title :

Impact of mismatch repair deficiency on tumour regression grade after neoadjuvant chemotherapy in localized gastroesophageal adenocarcinoma

Author(s) :

Heran, Maximilien [Auteur]
CHU Saint-Antoine [AP-HP]
Renaud, Florence [Auteur]
Hôpital Claude Huriez [Lille]
Louvet, Christophe [Auteur]
Institut Mutualiste de Montsouris [IMM]
Piessen, Guillaume [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Voron, Thibault [Auteur]
CHU Saint-Antoine [AP-HP]
Lefèvre, Marine [Auteur]
Institut Mutualiste de Montsouris [IMM]
Dubreuil, Olivier [Auteur]
Groupe Hospitalier Diaconesses Croix Saint-Simon
André, Thierry [Auteur]
CHU Saint-Antoine [AP-HP]
Instabilité des microsatellites et cancers [CRSA]
Svrcek, Magali [Auteur]
CHU Saint-Antoine [AP-HP]
Cohen, Romain [Auteur]
CHU Saint-Antoine [AP-HP]
Instabilité des microsatellites et cancers [CRSA]

Journal title :

Digestive and Liver Disease

Publisher :

Elsevier

Publication date :

2022-06-29

ISSN :

1590-8658

English keyword(s) :

Biomarker
Gastric cancer
Localized cancer
Microsatellite instability
Mismatch repair

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: The use of neoadjuvant chemotherapy (NAC) in patients with mismatch repair (MMR) deficient (dMMR) localized gastric and oeso-gastric junction (OGJ) adenocarcinoma is subject of debate. Histological response ...
Show more >Background: The use of neoadjuvant chemotherapy (NAC) in patients with mismatch repair (MMR) deficient (dMMR) localized gastric and oeso-gastric junction (OGJ) adenocarcinoma is subject of debate. Histological response assessment might help to better evaluate the impact of dMMR on response to NAC.Methods: Patients with localized gastric/OGJ adenocarcinoma resected after NAC were retrospectively identified. MMR protein expression status was assessed by immunohistochemistry. The primary objective was the frequency of histological responders to NAC defined by tumour regression grade (TRG) using Mandard's (TRG1-2) and Becker's (TRG1) classifications, according to the MMR status.Results: In total, 247 patients with 43 dMMR and 204 pMMR gastric/OGJ adenocarcinoma were identified. Among dMMR tumours, 18 (42%) arose from the OGJ. Histological response (Becker TRG1-2) was observed for 28% and 35% of dMMR and pMMR tumours, respectively (p = 0.35). Similar results were observed with Mandard classification. With a median follow-up of 37.5 months, median disease-free and overall survival were not reached for the dMMR group.Conclusion: Histological response after NAC in patients with localized dMMR gastric/OGJ adenocarcinoma is not statistically different to those with pMMR tumours. This study provides additional data for the discussion about avoiding NAC in patients with dMMR gastric/OGJ adenocarcinomas.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Submission date :

2024-02-17T03:50:44Z