EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?

Type de document :

Compte-rendu et recension critique d'ouvrage

DOI :

10.1021/acs.jmedchem.9b02001

PMID :

URL permanente :

http://hdl.handle.net/20.500.12210/108105

Titre :

EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?

Auteur(s) :

Liberelle, Maxime [Auteur]

Lille Neurosciences & Cognition - U 1172 [LilNCog]
Jonckheere, Nicolas [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Melnyk, Patricia [Auteur]

Lille Neurosciences & Cognition - U 1172 [LilNCog]
Van Seuningen, Isabelle [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Lebègue, Nicolas [Auteur correspondant]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Titre de la revue :

Journal of Medicinal Chemistry

Pagination :

5074-5088

Éditeur :

American Chemical Society

Date de publication :

2020-02-13

ISSN :

0022-2623

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

Membrane-bound mucins belong to a heterogeneous family of large O-glycoproteins involved in numerous cancers and inflammatory diseases of the epithelium. Some of them are also involved in protein–protein interactions, with ...
Lire la suite >Membrane-bound mucins belong to a heterogeneous family of large O-glycoproteins involved in numerous cancers and inflammatory diseases of the epithelium. Some of them are also involved in protein–protein interactions, with receptor tyrosine kinase ErbB2, and fundamental and clinical data showed that these complexes have a detrimental impact on cancer outcome, thus raising interest in therapeutic targeting. This paper aims to demonstrate that MUC3, MUC4, MUC12, MUC13, and MUC17 have a common evolutionary origin and share a common structural organization with EGF-like and SEA domains. Theoretical structure–function relationship analysis of the conserved domains indicated that the studied membrane-bound mucins share common biological properties along with potential specific functions. Finally, the potential druggability of these complexes is discussed, revealing ErbB2-related pathways of cell signaling to be targeted.Lire moins >

Langue :

Anglais

Vulgarisation :

Non

Collections :

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Date de dépôt :

2024-02-17T04:29:59Z